Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334787752> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2334787752 abstract "MiRNA expression profile of human cancers has been characterized by an overall miRNA downregulation. While the causes include a transcriptional silencing and a failure of miRNA maturation, another possibility is that the deregulation of the machinery components for executing miRNA function also may cause similar consequences. Then, we screened the protein expression levels of the established members of the miRNA-containing ribonucleoproteins (Dicer, Ago2, TRBP2, DDX20 also known as Gemin3, and Gemin4) in various organ cancers by immunohisotchemistry. We detected reduced expression of DDX20 only in hepatocellular carcinoma tissues, while the levels of other genes were not drastically changed. We show that DDX20 suppresses NF-κB activity through regulating a subset of miRNA function. A microRNA library screen revealed that miR-140-3p and miR-22 suppress NF-κB activation by targeting the expression of NRIP1 and NCOA1, both are coactivators of NF-κB. However, in DDX20 deficient cells, this suppressive effect was lost, leading to NF-κB activation, a key regulator of hepatocarcinogenesis. In addition, DDX20 knockdown indeed induced cell transformation, revealed by a sphere-forming assay. These results indicate that DDX20 deficiency enhances NF-κB activity by impairing the NF-κB-suppressive action of microRNAs, and suggest that deregulation of the microRNA machinery may be one of the mechanisms of oncogenesis in liver cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3978. doi:10.1158/1538-7445.AM2011-3978" @default.
- W2334787752 created "2016-06-24" @default.
- W2334787752 creator A5023823880 @default.
- W2334787752 creator A5024035957 @default.
- W2334787752 creator A5026907725 @default.
- W2334787752 creator A5034244372 @default.
- W2334787752 creator A5039237617 @default.
- W2334787752 creator A5046522736 @default.
- W2334787752 creator A5053550013 @default.
- W2334787752 creator A5059311581 @default.
- W2334787752 creator A5060570462 @default.
- W2334787752 creator A5064957678 @default.
- W2334787752 creator A5076244197 @default.
- W2334787752 date "2011-04-15" @default.
- W2334787752 modified "2023-10-02" @default.
- W2334787752 title "Abstract 3978: DDX20, a suppressor of hepatocarcinogenesis, controls NF-κB activity through regulating the function of miRNA-22 and miRNA-140-3p targeting transcriptional coactivators" @default.
- W2334787752 doi "https://doi.org/10.1158/1538-7445.am2011-3978" @default.
- W2334787752 hasPublicationYear "2011" @default.
- W2334787752 type Work @default.
- W2334787752 sameAs 2334787752 @default.
- W2334787752 citedByCount "0" @default.
- W2334787752 crossrefType "proceedings-article" @default.
- W2334787752 hasAuthorship W2334787752A5023823880 @default.
- W2334787752 hasAuthorship W2334787752A5024035957 @default.
- W2334787752 hasAuthorship W2334787752A5026907725 @default.
- W2334787752 hasAuthorship W2334787752A5034244372 @default.
- W2334787752 hasAuthorship W2334787752A5039237617 @default.
- W2334787752 hasAuthorship W2334787752A5046522736 @default.
- W2334787752 hasAuthorship W2334787752A5053550013 @default.
- W2334787752 hasAuthorship W2334787752A5059311581 @default.
- W2334787752 hasAuthorship W2334787752A5060570462 @default.
- W2334787752 hasAuthorship W2334787752A5064957678 @default.
- W2334787752 hasAuthorship W2334787752A5076244197 @default.
- W2334787752 hasConcept C104317684 @default.
- W2334787752 hasConcept C119056186 @default.
- W2334787752 hasConcept C121608353 @default.
- W2334787752 hasConcept C127561419 @default.
- W2334787752 hasConcept C145059251 @default.
- W2334787752 hasConcept C166703698 @default.
- W2334787752 hasConcept C173396325 @default.
- W2334787752 hasConcept C179185449 @default.
- W2334787752 hasConcept C190283241 @default.
- W2334787752 hasConcept C2779867133 @default.
- W2334787752 hasConcept C502942594 @default.
- W2334787752 hasConcept C54355233 @default.
- W2334787752 hasConcept C555283112 @default.
- W2334787752 hasConcept C67705224 @default.
- W2334787752 hasConcept C6929976 @default.
- W2334787752 hasConcept C86803240 @default.
- W2334787752 hasConceptScore W2334787752C104317684 @default.
- W2334787752 hasConceptScore W2334787752C119056186 @default.
- W2334787752 hasConceptScore W2334787752C121608353 @default.
- W2334787752 hasConceptScore W2334787752C127561419 @default.
- W2334787752 hasConceptScore W2334787752C145059251 @default.
- W2334787752 hasConceptScore W2334787752C166703698 @default.
- W2334787752 hasConceptScore W2334787752C173396325 @default.
- W2334787752 hasConceptScore W2334787752C179185449 @default.
- W2334787752 hasConceptScore W2334787752C190283241 @default.
- W2334787752 hasConceptScore W2334787752C2779867133 @default.
- W2334787752 hasConceptScore W2334787752C502942594 @default.
- W2334787752 hasConceptScore W2334787752C54355233 @default.
- W2334787752 hasConceptScore W2334787752C555283112 @default.
- W2334787752 hasConceptScore W2334787752C67705224 @default.
- W2334787752 hasConceptScore W2334787752C6929976 @default.
- W2334787752 hasConceptScore W2334787752C86803240 @default.
- W2334787752 hasLocation W23347877521 @default.
- W2334787752 hasOpenAccess W2334787752 @default.
- W2334787752 hasPrimaryLocation W23347877521 @default.
- W2334787752 hasRelatedWork W1825148365 @default.
- W2334787752 hasRelatedWork W1985405118 @default.
- W2334787752 hasRelatedWork W2001428704 @default.
- W2334787752 hasRelatedWork W2020175162 @default.
- W2334787752 hasRelatedWork W2026151061 @default.
- W2334787752 hasRelatedWork W2034203463 @default.
- W2334787752 hasRelatedWork W2038167014 @default.
- W2334787752 hasRelatedWork W2094205550 @default.
- W2334787752 hasRelatedWork W2326750180 @default.
- W2334787752 hasRelatedWork W2331656592 @default.
- W2334787752 hasRelatedWork W2590831403 @default.
- W2334787752 hasRelatedWork W2792034745 @default.
- W2334787752 hasRelatedWork W2886280456 @default.
- W2334787752 hasRelatedWork W2922151888 @default.
- W2334787752 hasRelatedWork W2981119268 @default.
- W2334787752 hasRelatedWork W3008535958 @default.
- W2334787752 hasRelatedWork W3012691784 @default.
- W2334787752 hasRelatedWork W3083260706 @default.
- W2334787752 hasRelatedWork W3122501282 @default.
- W2334787752 hasRelatedWork W340317714 @default.
- W2334787752 isParatext "false" @default.
- W2334787752 isRetracted "false" @default.
- W2334787752 magId "2334787752" @default.
- W2334787752 workType "article" @default.