Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334803407> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2334803407 abstract "1354 Objectives: To evaluate therapeutic effect of combined therapy with radioiodine and ganciclovir (GCV) in hepatocellular carcinoma cell using NIS and HSV1-sr39tk gene, a construct encoding triple genes were transfected into Huh-7 cell and its therapeutic effect were assessed in animal model. Methods: We constructed a vector encoding NIS, HSV1-sr39tk and GFP gene and the vector was transfected to Huh-7 cell(NTG cell).In vitro cytotoxic effect was measured after GCV and I-131 treatment.For in vivo therapy, 1X107 of NTG and Huh-7cells were transplanted into both thighs of nude mice. In I-131 group, the mice were treated with ip injection of 1.5mCi of I-131. In GCV group was treated with 30mg/kg of GCV every 2 d. for 2 wks. In dual therapy group, the mice were treated with 1.5mCi of I-131 and 30mg/kg of GCV. Results: The cell viability of NTG cell was decreased to 38% at 10ug/ml GCV concentration. The survival rate of the NTG cell decreased up to 16% with I-131 in vitro. Tumoral growth rate was lesser for NTG tumor at 2 weeks after GCV or I-131 treatment, those are 32.5% and 79.5% of respectively. Dual therapy with GCV and I-131 resulted in further decreases in growth rate and that was 27.3% compared to control NTG tumor. Conclusions: Combination therapy with I-131 and GCV on hepatocellular carcinoma cell transfected with NIS and HSV1-sr39tk gene was effective in in-vitro as well as in-vivo. Also, the monitoring of therapeutic effect of dual gene could be easily assessed by the optical reporter gene imaging. Research Support: This work was supported by the Brain Korea 21 Project in 2008." @default.
- W2334803407 created "2016-06-24" @default.
- W2334803407 creator A5004270946 @default.
- W2334803407 creator A5009204601 @default.
- W2334803407 creator A5020166913 @default.
- W2334803407 creator A5045189061 @default.
- W2334803407 creator A5047692659 @default.
- W2334803407 creator A5051978834 @default.
- W2334803407 creator A5058260647 @default.
- W2334803407 creator A5073280158 @default.
- W2334803407 creator A5082652350 @default.
- W2334803407 creator A5086869445 @default.
- W2334803407 date "2008-05-01" @default.
- W2334803407 modified "2023-09-23" @default.
- W2334803407 title "Incremental therapeutic effect and monitoring response using triple reporter gene (NIS, HSV1-sr39tk, and GFP) in Huh-7 cell xenografted mice" @default.
- W2334803407 hasPublicationYear "2008" @default.
- W2334803407 type Work @default.
- W2334803407 sameAs 2334803407 @default.
- W2334803407 citedByCount "0" @default.
- W2334803407 crossrefType "journal-article" @default.
- W2334803407 hasAuthorship W2334803407A5004270946 @default.
- W2334803407 hasAuthorship W2334803407A5009204601 @default.
- W2334803407 hasAuthorship W2334803407A5020166913 @default.
- W2334803407 hasAuthorship W2334803407A5045189061 @default.
- W2334803407 hasAuthorship W2334803407A5047692659 @default.
- W2334803407 hasAuthorship W2334803407A5051978834 @default.
- W2334803407 hasAuthorship W2334803407A5058260647 @default.
- W2334803407 hasAuthorship W2334803407A5073280158 @default.
- W2334803407 hasAuthorship W2334803407A5082652350 @default.
- W2334803407 hasAuthorship W2334803407A5086869445 @default.
- W2334803407 hasConcept C104317684 @default.
- W2334803407 hasConcept C111599444 @default.
- W2334803407 hasConcept C126322002 @default.
- W2334803407 hasConcept C1491633281 @default.
- W2334803407 hasConcept C150194340 @default.
- W2334803407 hasConcept C150903083 @default.
- W2334803407 hasConcept C153911025 @default.
- W2334803407 hasConcept C161733203 @default.
- W2334803407 hasConcept C185592680 @default.
- W2334803407 hasConcept C202751555 @default.
- W2334803407 hasConcept C207001950 @default.
- W2334803407 hasConcept C2777965375 @default.
- W2334803407 hasConcept C2779820661 @default.
- W2334803407 hasConcept C2911091166 @default.
- W2334803407 hasConcept C502942594 @default.
- W2334803407 hasConcept C54009773 @default.
- W2334803407 hasConcept C55493867 @default.
- W2334803407 hasConcept C71924100 @default.
- W2334803407 hasConcept C86803240 @default.
- W2334803407 hasConcept C98274493 @default.
- W2334803407 hasConceptScore W2334803407C104317684 @default.
- W2334803407 hasConceptScore W2334803407C111599444 @default.
- W2334803407 hasConceptScore W2334803407C126322002 @default.
- W2334803407 hasConceptScore W2334803407C1491633281 @default.
- W2334803407 hasConceptScore W2334803407C150194340 @default.
- W2334803407 hasConceptScore W2334803407C150903083 @default.
- W2334803407 hasConceptScore W2334803407C153911025 @default.
- W2334803407 hasConceptScore W2334803407C161733203 @default.
- W2334803407 hasConceptScore W2334803407C185592680 @default.
- W2334803407 hasConceptScore W2334803407C202751555 @default.
- W2334803407 hasConceptScore W2334803407C207001950 @default.
- W2334803407 hasConceptScore W2334803407C2777965375 @default.
- W2334803407 hasConceptScore W2334803407C2779820661 @default.
- W2334803407 hasConceptScore W2334803407C2911091166 @default.
- W2334803407 hasConceptScore W2334803407C502942594 @default.
- W2334803407 hasConceptScore W2334803407C54009773 @default.
- W2334803407 hasConceptScore W2334803407C55493867 @default.
- W2334803407 hasConceptScore W2334803407C71924100 @default.
- W2334803407 hasConceptScore W2334803407C86803240 @default.
- W2334803407 hasConceptScore W2334803407C98274493 @default.
- W2334803407 hasOpenAccess W2334803407 @default.
- W2334803407 hasRelatedWork W2023574403 @default.
- W2334803407 hasRelatedWork W2077955418 @default.
- W2334803407 hasRelatedWork W2127961596 @default.
- W2334803407 hasRelatedWork W2150256056 @default.
- W2334803407 hasRelatedWork W2348446518 @default.
- W2334803407 hasRelatedWork W2357458801 @default.
- W2334803407 hasRelatedWork W2363410292 @default.
- W2334803407 hasRelatedWork W2367177560 @default.
- W2334803407 hasRelatedWork W2371636920 @default.
- W2334803407 hasRelatedWork W2377937415 @default.
- W2334803407 hasRelatedWork W2385137795 @default.
- W2334803407 hasRelatedWork W2388587546 @default.
- W2334803407 hasRelatedWork W2392931223 @default.
- W2334803407 hasRelatedWork W2415295336 @default.
- W2334803407 hasRelatedWork W2416361955 @default.
- W2334803407 hasRelatedWork W2418755397 @default.
- W2334803407 hasRelatedWork W2422998961 @default.
- W2334803407 hasRelatedWork W3023791812 @default.
- W2334803407 hasRelatedWork W3029046319 @default.
- W2334803407 hasRelatedWork W3031254818 @default.
- W2334803407 hasVolume "49" @default.
- W2334803407 isParatext "false" @default.
- W2334803407 isRetracted "false" @default.
- W2334803407 magId "2334803407" @default.
- W2334803407 workType "article" @default.