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• W2334807580 abstract "Objectives To compare 24 h ambulatory blood pressure and trough office blood pressure lowerings after 8 weeks of therapy with 75 mg irbesartan once a day, 150 mg irbesartan once a day, and 75 mg irbesartan twice a day versus placebo; and to assess safety and tolerability of irbesartan therapy. Design Multicenter, double-blind, randomized, placebo-controlled trial. Setting Sixteen centers in Italy. Patients Caucasian patients (n = 215) aged ≥ 18 years with seated diastolic blood pressure 95–110 mmHg and ambulatory diastolic blood pressure (ADBP) ≥ 85 mmHg. Primary outcome Mean 24 h ADBP after 8 weeks of irbesartan therapy. Results Mean changes (value before treatment minus value after treatment) in ADBP for placebo, 75 mg irbesartan once a day, 150 mg irbesartan once a day, and 75 mg irbesartan twice a day were −0.2, −5.4, −7.2, and −7.2 mmHg, respectively; respective changes in ambulatory systolic blood pressure were +1.6, −8.3, −10.5, and −9.7 mmHg. All irbesartan regimens reduced trough office seated diastolic blood pressure and seated systolic blood pressure after 2 and 8 weeks of treatment (all P < 0.01, versus placebo except for seated systolic blood pressure in patients in the 75 mg irbesartan once a day group). Trough: peak ratios were ≥ 55% with 150 mg irbesartan once a day. Percentages of patients whose blood pressures were normalized with 150 mg irbesartan once a day (45%) and 75 mg irbesartan twice a day (47%) were greater than those with placebo (14%, P < 0.01) and with 75 mg irbesartan once a day (19%, NS, versus placebo). Adverse events with irbesartan were similar to those with placebo. Conclusions All irbesartan regimens significantly reduced mean 24 h ADBP and ambulatory systolic blood pressure, and were well tolerated. Administration of 150 mg irbesartan once a day provided significant reduction of blood pressure for 24 h, equivalent to that obtained with the same daily dose divided into two separate administrations." @default.
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• W2334807580 date "1997-12-01" @default.
• W2334807580 modified "2023-09-23" @default.
• W2334807580 title "24-Hour blood pressure control by once-daily administration of irbesartan assessed by ambulatory blood pressure monitoring" @default.
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• W2334807580 doi "https://doi.org/10.1097/00004872-199715120-00020" @default.
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