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- W2334822079 endingPage "291" @default.
- W2334822079 startingPage "285" @default.
- W2334822079 abstract "Periodontitis is a dysbiotic inflammatory disease leading to the destruction of the tooth-supporting tissues. Current therapies are not always effective and this prevalent oral disease continues to be a significant health and economic burden. Early clinical studies have associated periodontitis with elevated complement activity. Consistently, subsequent genetic and pharmacological studies in rodents have implicated the central complement component C3 and downstream signaling pathways in periodontal host-microbe interactions that promote dysbiosis and inflammatory bone loss. This review discusses these mechanistic advances and moreover focuses on the compstatin family of C3 inhibitors as a novel approach to treat periodontitis. In this regard, local application of the current lead analog Cp40 was recently shown to block both inducible and naturally occurring periodontitis in non-human primates. These promising results from non-human primate studies and the parallel development of Cp40 for clinical use highlight the feasibility for developing an adjunctive, C3-targeted therapy for human periodontitis." @default.
- W2334822079 created "2016-06-24" @default.
- W2334822079 creator A5014734520 @default.
- W2334822079 creator A5056886927 @default.
- W2334822079 creator A5071133928 @default.
- W2334822079 creator A5072786504 @default.
- W2334822079 creator A5074106869 @default.
- W2334822079 creator A5074301183 @default.
- W2334822079 creator A5084031628 @default.
- W2334822079 date "2016-06-01" @default.
- W2334822079 modified "2023-10-17" @default.
- W2334822079 title "Complement inhibition in pre-clinical models of periodontitis and prospects for clinical application" @default.
- W2334822079 cites W1489377217 @default.
- W2334822079 cites W1525531948 @default.
- W2334822079 cites W1574593386 @default.
- W2334822079 cites W1597826715 @default.
- W2334822079 cites W1639629788 @default.
- W2334822079 cites W1691524838 @default.
- W2334822079 cites W1826628219 @default.
- W2334822079 cites W1884635290 @default.
- W2334822079 cites W1911897482 @default.
- W2334822079 cites W1925485130 @default.
- W2334822079 cites W1925706324 @default.
- W2334822079 cites W1938827771 @default.
- W2334822079 cites W1945298518 @default.
- W2334822079 cites W1947627842 @default.
- W2334822079 cites W1964544797 @default.
- W2334822079 cites W1967309573 @default.
- W2334822079 cites W1969787878 @default.
- W2334822079 cites W1975295516 @default.
- W2334822079 cites W1986592145 @default.
- W2334822079 cites W1991185249 @default.
- W2334822079 cites W1993128745 @default.
- W2334822079 cites W2003373507 @default.
- W2334822079 cites W2004487653 @default.
- W2334822079 cites W2005044790 @default.
- W2334822079 cites W2007559967 @default.
- W2334822079 cites W2008294135 @default.
- W2334822079 cites W2008601904 @default.
- W2334822079 cites W2010309316 @default.
- W2334822079 cites W2017295943 @default.
- W2334822079 cites W2020008649 @default.
- W2334822079 cites W2021272086 @default.
- W2334822079 cites W2021838232 @default.
- W2334822079 cites W2027752581 @default.
- W2334822079 cites W2028226122 @default.
- W2334822079 cites W2029594785 @default.
- W2334822079 cites W2031215908 @default.
- W2334822079 cites W2036209716 @default.
- W2334822079 cites W2038191439 @default.
- W2334822079 cites W2041896408 @default.
- W2334822079 cites W2042425014 @default.
- W2334822079 cites W2042863644 @default.
- W2334822079 cites W2049967795 @default.
- W2334822079 cites W2051654094 @default.
- W2334822079 cites W2053205462 @default.
- W2334822079 cites W2056938675 @default.
- W2334822079 cites W2058313496 @default.
- W2334822079 cites W2059697362 @default.
- W2334822079 cites W2064610856 @default.
- W2334822079 cites W2066151306 @default.
- W2334822079 cites W2069697252 @default.
- W2334822079 cites W2074150122 @default.
- W2334822079 cites W2083175247 @default.
- W2334822079 cites W2088297260 @default.
- W2334822079 cites W2089481411 @default.
- W2334822079 cites W2090178061 @default.
- W2334822079 cites W2090443712 @default.
- W2334822079 cites W2094534201 @default.
- W2334822079 cites W2095060158 @default.
- W2334822079 cites W2096252424 @default.
- W2334822079 cites W2098912990 @default.
- W2334822079 cites W2098976315 @default.
- W2334822079 cites W2100902668 @default.
- W2334822079 cites W2107489987 @default.
- W2334822079 cites W2108571057 @default.
- W2334822079 cites W2109533208 @default.
- W2334822079 cites W2113038626 @default.
- W2334822079 cites W2113542718 @default.
- W2334822079 cites W2114326652 @default.
- W2334822079 cites W2116253816 @default.
- W2334822079 cites W2116360496 @default.
- W2334822079 cites W2118238110 @default.
- W2334822079 cites W2119007673 @default.
- W2334822079 cites W2123649398 @default.
- W2334822079 cites W2127086648 @default.
- W2334822079 cites W2132733711 @default.
- W2334822079 cites W2133941441 @default.
- W2334822079 cites W2136648677 @default.
- W2334822079 cites W2139905546 @default.
- W2334822079 cites W2146766390 @default.
- W2334822079 cites W2148445732 @default.
- W2334822079 cites W2149150871 @default.
- W2334822079 cites W2151114218 @default.
- W2334822079 cites W2154748957 @default.
- W2334822079 cites W2155905632 @default.
- W2334822079 cites W2156303340 @default.
- W2334822079 cites W2159326694 @default.