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- W2334833027 abstract "The current contribution aims to prepare a family of nitrofurantoin (NF) co-crystals and to investigate the ability of these co-crystals in enhancing the photostability and clinically relevant physicochemical properties of NF. Accordingly, supramolecular synthesis of the antibiotic drug NF with the co-formers 3-aminobenzoic acid (3ABA), 4-aminobenzoic acid (4ABA), urea, 4-hydroxybenzamide (4HBAM), phenazine (PHEN), melamine (MELA), 4,4′-bipyridine (BIPY) and 1,2-bis(4-pyridyl ethane) (BIPE) have produced five co-crystals and three co-crystal hydrates. Solid-state physical characterizations have been conducted by powder X-ray diffraction (PXRD), single crystal X-ray diffraction, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), hot-stage microscopy (HSM) and spectroscopy (Raman and 1H NMR). Crystal structures have been analyzed based on homo- and heterosynthons. Six out of eight multicomponent crystals are primarily stabilized by heterosynthons, whereas the remaining two co-crystal..." @default.
- W2334833027 created "2016-06-24" @default.
- W2334833027 creator A5001323251 @default.
- W2334833027 creator A5034002389 @default.
- W2334833027 creator A5069512029 @default.
- W2334833027 date "2012-10-30" @default.
- W2334833027 modified "2023-10-16" @default.
- W2334833027 title "Co-Crystals and Co-Crystal Hydrates of the Antibiotic Nitrofurantoin: Structural Studies and Physicochemical Properties" @default.
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- W2334833027 doi "https://doi.org/10.1021/cg300887p" @default.
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