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• W2334852544 abstract "A total of 10 new indole alkaloids, tabercarpamines A–J (1–10), were isolated from the leaves of Tabernaemontana corymbosa. Tabercarpamines C–F (3–6) are rare C-14/C-15-seco-tabersonine-type monoterpenoid indole alkaloids, and 5 and 6 are the first examples with a lactone linkage between C-14 and C-20. The structures of these alkaloids were elucidated using spectroscopic methods, and the absolute configurations of 1 and 2 were determined using the ECD exciton chirality method. In addition, an MTT assay was used to examine the growth-inhibitory effects of all new isolates and of two known isolates on MCF-7, HepG2, and SMMC-7721 cells; 1 exhibited significant inhibitory effects against these three human cancer cell lines with IC50 values of 8.54, 3.31, and 6.76 μM, respectively. Additionally, the results from the annexin-V/PI double-staining assay indicated that 1 might inhibit the proliferation of HepG2 cells by inducing apoptosis." @default.
• W2334852544 created "2016-06-24" @default.
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• W2334852544 date "2014-04-28" @default.
• W2334852544 modified "2023-10-18" @default.
• W2334852544 title "Tabercarpamines A–J, Apoptosis-Inducing Indole Alkaloids from the Leaves of <i>Tabernaemontana corymbosa</i>" @default.
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• W2334852544 doi "https://doi.org/10.1021/np401098y" @default.
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