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- W2334854735 abstract "X-ray crystallography is a valuable tool for determining the three-dimensional structure of large biomolecules. Information gained from crystallographic studies is used to determine the function of proteins and other macromolecules in biological systems. A number of experimental processes are involved in determining the structure of a protein by crystallograp hy. Frequently, the most difficult step is producing large, single crystals for xray diffraction data collection. NASA's biotechnology research program explores new Earthand space-based techniques for crystallizing macromolecules. Under NASA funding, the Center for Biophysical Sciences and Engineering has developed an extensive assembly of space flight hardware to explore the effect of the microgravity environment on macromolecular crystal growth. The Center has conducted protein crystal growth experiments on 38 space shuttle missions. New crystallographic techniques for Earth- and spacebased experiments have improved researcher's ability to produce high quality macromolecular crystals. The application of structural information to understanding the function of proteins and developing new drugs is discussed." @default.
- W2334854735 created "2016-06-24" @default.
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- W2334854735 date "2001-01-08" @default.
- W2334854735 modified "2023-10-16" @default.
- W2334854735 title "Applications of protein crystallography in structural biology and drug design" @default.
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- W2334854735 doi "https://doi.org/10.2514/6.2001-325" @default.
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