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- W2334854834 abstract "1. For the purpose of clarifying the mechanism of mercapturic acid formation, properties of enzymes which catalyzed the conjugation of GSH with benzyl chloride (BzCl), bromobenzene (BrPh) and 3, 4-dichloronitrobenzene (DCNB) were examined in the liver of rats. 2. In addition to the supernatant fraction, a microsomal fraction was necessary for the enzymic conjugation of GSH with BrPh. 3. GSH-conjugating activity with BzCl was depleted in the liver of rats treated with BzCl. Either GSH-conjugating activity toward DCNB or BrPh did not show a significant change after the administration of each compound. 4. GSH-conjugating activity toward BrPh markedly increased in the liver of rats treated with phenobarbital, and its ratio of the stimulation was paralleled with that of aniline-hydroxylating activity. 5. It was assumed that increase of the activity of GSH-conjugation with BrPh by the treatment with phenobarbital was due to the induction of a microsomal oxygenase system." @default.
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- W2334854834 date "1970-01-01" @default.
- W2334854834 modified "2023-09-27" @default.
- W2334854834 title "Studies on Mercapturic Acids. Effect of Some Chemical Compounds on the Activities of Glutathione-conjugating Enzymes" @default.
- W2334854834 doi "https://doi.org/10.1248/cpb.18.115" @default.
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