Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334854965> ?p ?o ?g. }
- W2334854965 endingPage "1717" @default.
- W2334854965 startingPage "1708" @default.
- W2334854965 abstract "The α-subunit of eukaryotic initiation factor 2 (eIF2α) is a key translation regulator that plays an important role in cellular stress responses. In the present study, we investigated how eIF2α phosphorylation can be regulated by a tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) and how such regulation is used by PTEN-deficient hepatocytes to adapt and cope with oxidative stress. We found that eIF2α was hyperphosphorylated when Pten was deleted, and this process was AKT dependent. Consistent with this finding, we found that the Pten-null cells developed resistance to oxidative glutamate and H(2)O(2)-induced cellular toxicity. We showed that the messenger level of CReP (constitutive repressor of eIF2α phosphorylation), a constitutive phosphatase of eIF2α, was downregulated in Pten-null hepatocytes, providing a possible mechanism through which PTEN/AKT pathway regulates eIF2α phosphorylation. Ectopic expression of CReP restored the sensitivity of the Pten mutant hepatocytes to oxidative stress, confirming the functional significance of the downregulated CReP and upregulated phospho-eIF2α in the resistance of Pten mutant hepatocytes to cellular stress. In summary, our study suggested a novel role of PTEN in regulating stress response through modulating the CReP/eIF2α pathway." @default.
- W2334854965 created "2016-06-24" @default.
- W2334854965 creator A5018585776 @default.
- W2334854965 creator A5018747306 @default.
- W2334854965 creator A5022997397 @default.
- W2334854965 creator A5050911555 @default.
- W2334854965 creator A5073554386 @default.
- W2334854965 creator A5079426553 @default.
- W2334854965 creator A5091859665 @default.
- W2334854965 date "2011-12-01" @default.
- W2334854965 modified "2023-10-14" @default.
- W2334854965 title "Adaptive Basal Phosphorylation of eIF2α Is Responsible for Resistance to Cellular Stress–Induced Cell Death in <i>Pten</i>-Null Hepatocytes" @default.
- W2334854965 cites W1569469862 @default.
- W2334854965 cites W1966831322 @default.
- W2334854965 cites W1978895733 @default.
- W2334854965 cites W1993676495 @default.
- W2334854965 cites W2001800178 @default.
- W2334854965 cites W2003295985 @default.
- W2334854965 cites W2027821655 @default.
- W2334854965 cites W2034213169 @default.
- W2334854965 cites W2038625523 @default.
- W2334854965 cites W2049140233 @default.
- W2334854965 cites W2058093430 @default.
- W2334854965 cites W2062845561 @default.
- W2334854965 cites W2069348138 @default.
- W2334854965 cites W2070942270 @default.
- W2334854965 cites W2076131270 @default.
- W2334854965 cites W2080666240 @default.
- W2334854965 cites W2088045914 @default.
- W2334854965 cites W2096124677 @default.
- W2334854965 cites W2096691828 @default.
- W2334854965 cites W2100472948 @default.
- W2334854965 cites W2105286896 @default.
- W2334854965 cites W2108244474 @default.
- W2334854965 cites W2110999558 @default.
- W2334854965 cites W2118337893 @default.
- W2334854965 cites W2131234404 @default.
- W2334854965 cites W2139568257 @default.
- W2334854965 cites W2140663895 @default.
- W2334854965 cites W2141956267 @default.
- W2334854965 cites W2145994786 @default.
- W2334854965 cites W2156990953 @default.
- W2334854965 cites W2157224263 @default.
- W2334854965 cites W2170781174 @default.
- W2334854965 cites W2171654757 @default.
- W2334854965 doi "https://doi.org/10.1158/1541-7786.mcr-11-0299" @default.
- W2334854965 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4351767" @default.
- W2334854965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22009178" @default.
- W2334854965 hasPublicationYear "2011" @default.
- W2334854965 type Work @default.
- W2334854965 sameAs 2334854965 @default.
- W2334854965 citedByCount "27" @default.
- W2334854965 countsByYear W23348549652013 @default.
- W2334854965 countsByYear W23348549652014 @default.
- W2334854965 countsByYear W23348549652015 @default.
- W2334854965 countsByYear W23348549652016 @default.
- W2334854965 countsByYear W23348549652017 @default.
- W2334854965 countsByYear W23348549652018 @default.
- W2334854965 countsByYear W23348549652019 @default.
- W2334854965 countsByYear W23348549652020 @default.
- W2334854965 countsByYear W23348549652021 @default.
- W2334854965 countsByYear W23348549652022 @default.
- W2334854965 countsByYear W23348549652023 @default.
- W2334854965 crossrefType "journal-article" @default.
- W2334854965 hasAuthorship W2334854965A5018585776 @default.
- W2334854965 hasAuthorship W2334854965A5018747306 @default.
- W2334854965 hasAuthorship W2334854965A5022997397 @default.
- W2334854965 hasAuthorship W2334854965A5050911555 @default.
- W2334854965 hasAuthorship W2334854965A5073554386 @default.
- W2334854965 hasAuthorship W2334854965A5079426553 @default.
- W2334854965 hasAuthorship W2334854965A5091859665 @default.
- W2334854965 hasBestOaLocation W23348549651 @default.
- W2334854965 hasConcept C104317684 @default.
- W2334854965 hasConcept C105580179 @default.
- W2334854965 hasConcept C11960822 @default.
- W2334854965 hasConcept C149364088 @default.
- W2334854965 hasConcept C178666793 @default.
- W2334854965 hasConcept C2777609662 @default.
- W2334854965 hasConcept C2779549131 @default.
- W2334854965 hasConcept C2779638656 @default.
- W2334854965 hasConcept C502942594 @default.
- W2334854965 hasConcept C55493867 @default.
- W2334854965 hasConcept C62478195 @default.
- W2334854965 hasConcept C75217442 @default.
- W2334854965 hasConcept C86554907 @default.
- W2334854965 hasConcept C86803240 @default.
- W2334854965 hasConcept C95444343 @default.
- W2334854965 hasConceptScore W2334854965C104317684 @default.
- W2334854965 hasConceptScore W2334854965C105580179 @default.
- W2334854965 hasConceptScore W2334854965C11960822 @default.
- W2334854965 hasConceptScore W2334854965C149364088 @default.
- W2334854965 hasConceptScore W2334854965C178666793 @default.
- W2334854965 hasConceptScore W2334854965C2777609662 @default.
- W2334854965 hasConceptScore W2334854965C2779549131 @default.
- W2334854965 hasConceptScore W2334854965C2779638656 @default.
- W2334854965 hasConceptScore W2334854965C502942594 @default.
- W2334854965 hasConceptScore W2334854965C55493867 @default.
- W2334854965 hasConceptScore W2334854965C62478195 @default.