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- W2334857795 abstract "Background: Although human bocavirus type 1 (HBoV1) is a respiratory pathogen, presence of HBoV-DNA in secretions of asymptomatic children raised the question on the significance of HBoV-positive results. Methods: Archived specimens from a prospective, longitudinal study were tested for HBoV. A total of 94 children (aged 6–36 months) were HBoV(+) during 172 upper respiratory tract infection (URI) and/or acute otitis media (AOM) episodes. We used pyrosequencing of NP1, VP1 and VP2 genes to type HBoV and subtype HBoV1 in these specimens. Results: Of the specimens tested, HBoV-DNA were successfully sequenced in 128 (74%) samples from 70 children; all were HBoV type 1. Subtypes identified (n = 108) were LWK/TW (63%), LWK/BJ (20%), Bonn/BJ (16%) and LWK/KU3 (1%). Of 46 children for whom shedding pattern could be determined, viral clearance within 30 days (13–29 days) occurred in 28%; another 22% of children had no recurrence after 32–267 days. Prolonged virus presence of >30 days (34–181 days+) occurred in 22%; intermittent detection (61+ to 170+ days) in 20%. Infection with the same HBoV1 subtype after 4–5 negative samples (244 and 265 days interval) occurred in 4%. Infection with 2 different HBoV1 subtypes (29 and 87 days apart) occurred in only 4%. Newly acquired HBoV1-URI resulted in AOM in 53% of cases. Conclusions: Children with HBoV1 infection commonly shed for a prolonged period leading to repeated viral DNA detection. Recurrence after 8–9 months suggests possible persistence and reactivation. Infections with 2 different HBoV1 subtypes within 1-year period are uncommon. Newly acquired HBoV1-URI is often complicated by AOM." @default.
- W2334857795 created "2016-06-24" @default.
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- W2334857795 date "2016-05-01" @default.
- W2334857795 modified "2023-10-11" @default.
- W2334857795 title "Determining Persistence of Bocavirus DNA in the Respiratory Tract of Children by Pyrosequencing" @default.
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- W2334857795 doi "https://doi.org/10.1097/inf.0000000000001058" @default.
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