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- W2334878797 abstract "Background and Aims Opiates like morphine and fentanyl are commonly used for sedation in the NICU. There are reports implicating early opiate exposure as a risk factor for NEC in preterm infants. We aimed to investigate if exposure to opiates in the first week of life was a risk factor for subsequent NEC in preterm infants in our NICU. Methods Cases of NEC (Bell Stage ≥2) in infants Total exposure to opiates (morphine and fentanyl) between days 1 and 7 was tabulated from medical records and the database. Two-tailed Fisher’s exact test was used to calculate the risk. Results 27 infants with definite NEC were identified with mean GA (±SD) of 27.2(±2.1) weeks and BW of 998 (±348) g. 54 controls were matched with mean (±SD) GA 0f 27.3 (±2.2) weeks and BW of 972(±346) g. Exposure to opiates was not different between NEC and controls ( P = 0.63; Odds Ratio (95% CI) of 0.73 (0.28–1.91). Median (range) daily opiate over the first week in NEC infants (morphine dose equivalent) was 14.3 (0–259) µg/kg/day or approx. 0.6 (0–11) µg/kg/hour. Conclusions Early opiate exposure did not appear to be a significant risk factor for NEC in our population." @default.
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- W2334878797 date "2012-10-01" @default.
- W2334878797 modified "2023-09-24" @default.
- W2334878797 title "284 Opiate Administration to Preterm Infants - A Risk Factor for Necrotising Enterocolitis?" @default.
- W2334878797 doi "https://doi.org/10.1136/archdischild-2012-302724.0284" @default.
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