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- W2334879330 abstract "Introduction: While various REM sleep variables such as REM latency and REM density have already been associated with the clinical course of major depressive disorder (MDD), so far, it is unclear whether this applies also to REM sleep instability (RSI) [1]. Therefore, we examined if RSI was related to severity of depression at baseline (BL) and after treatment. Methods: In a total of 22 adult in-patients suffering from MDD both severity of depression with Hamilton Depression Scale (HAMD) and sleep with sleep-EEG were assessed at BL and again after six weeks of treatment (W6). RSI was determined for whole sleep period (RSItotal) and for thirds of sleep period (RSI1./3, RSI2./3, RSI3./3). HAMD subscores for various features of depression were also determined. Results: At BL, HAMD scores and RSI did not statistically correlate. At W6, a higher RSI1./3 was associated with higher HAMD scores. Descriptively, at W6, patients with no remission had higher RSI1./3 as compared to remitters. An increased RSItotal at BL did correlate with the HAMD sub-scores “vegetative symptoms”, “psychic anxiety” and “somatic anxiety” at W6. Conclusion: These preliminary results reveal that RSI may be a predictor for treatment outcome in major depression. A decreased RSI seems to be particularly associated with improved psychophysiological symptoms of depression and anxiety. Reference: [1] Riemann D et al. REM sleep instability – a new pathway for insomnia? Pharmacopsychiatry 2012; 45: 167 – 76" @default.
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- W2334879330 date "2013-09-13" @default.
- W2334879330 modified "2023-10-14" @default.
- W2334879330 title "REM sleep instability in major depression at baseline predicts residual level of anxiety after six weeks of treatment" @default.
- W2334879330 doi "https://doi.org/10.1055/s-0033-1353310" @default.
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