FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334885751> ?p ?o ?g. }

• W2334885751 endingPage "1989" @default.
• W2334885751 startingPage "1989" @default.
• W2334885751 abstract "Detection of EML4-ALK fusion gene and features associated with EGFR mutations in Chinese patients with non-small-cell lung cancer Miaomiao Wen, Xuejiao Wang, Ying Sun, Jinghua Xia, Liangbo Fan, Hao Xing, Zhipei Zhang, Xiaofei Li Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, People’s Republic of China Purpose: Echinoderm microtubule-associated protein-like 4–anaplastic lymphoma kinase (EML4-ALK) and epidermal growth factor receptor (EGFR) define specific molecular subsets of lung cancer with distinct clinical features. We aimed at revealing the clinical features of EML4-ALK fusion gene and EGFR mutation in non-small-cell lung cancer (NSCLC).Methods: We enrolled 694 Chinese patients with NSCLC for analysis. EML4-ALK fusion gene was analyzed by real-time polymerase chain reaction, and EGFR mutations were analyzed by amplified refractory mutation system.Results: Among the 694 patients, 60 (8.65%) patients had EML4-ALK fusions. In continuity correction χ2 test analysis, EML4-ALK fusion gene was correlated with sex, age, smoking status, and histology, but no significant association was observed between EML4-ALK fusion gene and clinical stage. A total of 147 (21.18%) patients had EGFR mutations. In concordance with previous reports, EGFR mutation was correlated with age, smoking status, histology, and clinical stage, whereas patient age was not significantly associated with EGFR mutation. Meanwhile, to our surprise, six (0.86%) patients had coexisting EML4-ALK fusions and EGFR mutations.Conclusion: EML4-ALK fusion gene defines a new molecular subset in patients with NSCLC. Six patients who harbored both EML4-ALK fusion genes and EGFR mutations were identified in our study. The EGFR mutations and the EML4-ALK fusion genes are coexistent. Keywords: NSCLC, EML4-ALK fusion gene, EGFR mutation, RT-PCR" @default.
• W2334885751 created "2016-06-24" @default.
• W2334885751 creator A5005815536 @default.
• W2334885751 creator A5008614333 @default.
• W2334885751 creator A5015614663 @default.
• W2334885751 creator A5024632544 @default.
• W2334885751 creator A5025270532 @default.
• W2334885751 creator A5029389146 @default.
• W2334885751 creator A5061868395 @default.
• W2334885751 creator A5084231663 @default.
• W2334885751 date "2016-04-01" @default.
• W2334885751 modified "2023-10-02" @default.
• W2334885751 title "Detection of EML4-ALK fusion gene and features associated with EGFR mutations in Chinese patients with non-small-cell lung cancer" @default.
• W2334885751 cites W1546009185 @default.
• W2334885751 cites W1977277223 @default.
• W2334885751 cites W2000397789 @default.
• W2334885751 cites W2022789032 @default.
• W2334885751 cites W2029218729 @default.
• W2334885751 cites W2030864655 @default.
• W2334885751 cites W2031159738 @default.
• W2334885751 cites W2037139573 @default.
• W2334885751 cites W2040636001 @default.
• W2334885751 cites W2043696829 @default.
• W2334885751 cites W2055402151 @default.
• W2334885751 cites W2094903176 @default.
• W2334885751 cites W2103225497 @default.
• W2334885751 cites W2106787323 @default.
• W2334885751 cites W2126945850 @default.
• W2334885751 cites W2130488043 @default.
• W2334885751 cites W2136549983 @default.
• W2334885751 cites W2138064097 @default.
• W2334885751 cites W2139110945 @default.
• W2334885751 cites W2139236349 @default.
• W2334885751 cites W2140363584 @default.
• W2334885751 cites W2142989887 @default.
• W2334885751 cites W2153345506 @default.
• W2334885751 cites W2161821474 @default.
• W2334885751 cites W2166084034 @default.
• W2334885751 cites W2166351918 @default.
• W2334885751 cites W2168106545 @default.
• W2334885751 cites W2170874935 @default.
• W2334885751 cites W2171981784 @default.
• W2334885751 cites W2172010139 @default.
• W2334885751 cites W2396624466 @default.
• W2334885751 doi "https://doi.org/10.2147/ott.s100303" @default.
• W2334885751 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4827902" @default.
• W2334885751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27103824" @default.
• W2334885751 hasPublicationYear "2016" @default.
• W2334885751 type Work @default.
• W2334885751 sameAs 2334885751 @default.
• W2334885751 citedByCount "20" @default.
• W2334885751 countsByYear W23348857512016 @default.
• W2334885751 countsByYear W23348857512017 @default.
• W2334885751 countsByYear W23348857512018 @default.
• W2334885751 countsByYear W23348857512019 @default.
• W2334885751 countsByYear W23348857512021 @default.
• W2334885751 countsByYear W23348857512022 @default.
• W2334885751 countsByYear W23348857512023 @default.
• W2334885751 crossrefType "journal-article" @default.
• W2334885751 hasAuthorship W2334885751A5005815536 @default.
• W2334885751 hasAuthorship W2334885751A5008614333 @default.
• W2334885751 hasAuthorship W2334885751A5015614663 @default.
• W2334885751 hasAuthorship W2334885751A5024632544 @default.
• W2334885751 hasAuthorship W2334885751A5025270532 @default.
• W2334885751 hasAuthorship W2334885751A5029389146 @default.
• W2334885751 hasAuthorship W2334885751A5061868395 @default.
• W2334885751 hasAuthorship W2334885751A5084231663 @default.
• W2334885751 hasBestOaLocation W23348857511 @default.
• W2334885751 hasConcept C104317684 @default.
• W2334885751 hasConcept C111829193 @default.
• W2334885751 hasConcept C117643217 @default.
• W2334885751 hasConcept C121608353 @default.
• W2334885751 hasConcept C126322002 @default.
• W2334885751 hasConcept C143998085 @default.
• W2334885751 hasConcept C2776232967 @default.
• W2334885751 hasConcept C2776256026 @default.
• W2334885751 hasConcept C2779438470 @default.
• W2334885751 hasConcept C2994225774 @default.
• W2334885751 hasConcept C501734568 @default.
• W2334885751 hasConcept C502942594 @default.
• W2334885751 hasConcept C54355233 @default.
• W2334885751 hasConcept C71924100 @default.
• W2334885751 hasConcept C86803240 @default.
• W2334885751 hasConceptScore W2334885751C104317684 @default.
• W2334885751 hasConceptScore W2334885751C111829193 @default.
• W2334885751 hasConceptScore W2334885751C117643217 @default.
• W2334885751 hasConceptScore W2334885751C121608353 @default.
• W2334885751 hasConceptScore W2334885751C126322002 @default.
• W2334885751 hasConceptScore W2334885751C143998085 @default.
• W2334885751 hasConceptScore W2334885751C2776232967 @default.
• W2334885751 hasConceptScore W2334885751C2776256026 @default.
• W2334885751 hasConceptScore W2334885751C2779438470 @default.
• W2334885751 hasConceptScore W2334885751C2994225774 @default.
• W2334885751 hasConceptScore W2334885751C501734568 @default.
• W2334885751 hasConceptScore W2334885751C502942594 @default.
• W2334885751 hasConceptScore W2334885751C54355233 @default.
• W2334885751 hasConceptScore W2334885751C71924100 @default.
• W2334885751 hasConceptScore W2334885751C86803240 @default.

• next