Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334887951> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2334887951 endingPage "1696" @default.
- W2334887951 startingPage "1687" @default.
- W2334887951 abstract "Background Increases in vascular resistance (or the reciprocal, vascular conductance) in response to constrictor drugs are amplified (or attenuated) in the hindquarter vascular bed of hypertensive rats and rabbits. However, such changes have not been observed for the total peripheral circulation. Objective To assess whether the vascular amplifier applies to the total peripheral circulation in conscious hypertensive rabbits. Methods Rabbits were implanted with a flow probe for measuring cardiac output, a left atrial catheter for infusing dilator (adenosine) and constrictor (methoxamine) drugs, and ear artery and vein catheters for measuring mean arterial pressure (MAP) and for giving ganglion blockade. Data from full dose-total peripheral resistance (TPR) or total peripheral conductance (TPC) response curves to adenosine and methoxamine were combined into a logistic function extending from near full dilatation to near maximum constriction. Results Changes in MAP induced by methoxamine and adenosine were markedly greater in the ‘wrap’ rabbits (those with renal cellophane wrapping) compared with the sham animals. In the ‘wrap’ rabbits, the slopes and ranges of the adenosine-TPR response curve and the methoxamine-TPC response curve were 200% and 60%, respectively, of sham values. These data show that TPR changes are amplified, and TPC changes attenuated, to dilator and constrictor stimuli. The relationship between dose-average vascular radius (𝙧̅; based on Poiseuille's law) over the full range of vascular tone showed that 𝙧̅ was narrower in hypertension, but, in contrast to TPR, the degree of narrowing was almost the same between maximum dilatation and constriction. Conclusion The total peripheral circulation in experimental hypertension is a TPR amplifier, or TPC attenuator, in the rabbit, consistent with well-established data in the major vascular beds." @default.
- W2334887951 created "2016-06-24" @default.
- W2334887951 creator A5028183600 @default.
- W2334887951 creator A5032362251 @default.
- W2334887951 date "1999-12-01" @default.
- W2334887951 modified "2023-10-03" @default.
- W2334887951 title "Enhanced total peripheral vascular responsiveness in hypertension accords with the amplifier hypothesis" @default.
- W2334887951 cites W1765750524 @default.
- W2334887951 cites W1984107335 @default.
- W2334887951 cites W1992388654 @default.
- W2334887951 cites W1993647109 @default.
- W2334887951 cites W1994140988 @default.
- W2334887951 cites W1995945553 @default.
- W2334887951 cites W2003269305 @default.
- W2334887951 cites W2021384675 @default.
- W2334887951 cites W2037142508 @default.
- W2334887951 cites W2062613055 @default.
- W2334887951 cites W2063066510 @default.
- W2334887951 cites W2077772456 @default.
- W2334887951 cites W2097925949 @default.
- W2334887951 cites W2103810068 @default.
- W2334887951 cites W2122454953 @default.
- W2334887951 cites W2123841491 @default.
- W2334887951 cites W2138206726 @default.
- W2334887951 cites W2327082213 @default.
- W2334887951 doi "https://doi.org/10.1097/00004872-199917120-00005" @default.
- W2334887951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10658934" @default.
- W2334887951 hasPublicationYear "1999" @default.
- W2334887951 type Work @default.
- W2334887951 sameAs 2334887951 @default.
- W2334887951 citedByCount "34" @default.
- W2334887951 countsByYear W23348879512012 @default.
- W2334887951 countsByYear W23348879512013 @default.
- W2334887951 countsByYear W23348879512014 @default.
- W2334887951 countsByYear W23348879512015 @default.
- W2334887951 countsByYear W23348879512016 @default.
- W2334887951 countsByYear W23348879512017 @default.
- W2334887951 countsByYear W23348879512019 @default.
- W2334887951 countsByYear W23348879512020 @default.
- W2334887951 crossrefType "journal-article" @default.
- W2334887951 hasAuthorship W2334887951A5028183600 @default.
- W2334887951 hasAuthorship W2334887951A5032362251 @default.
- W2334887951 hasConcept C126322002 @default.
- W2334887951 hasConcept C164705383 @default.
- W2334887951 hasConcept C170493617 @default.
- W2334887951 hasConcept C174940676 @default.
- W2334887951 hasConcept C2776991684 @default.
- W2334887951 hasConcept C2777032099 @default.
- W2334887951 hasConcept C2778938600 @default.
- W2334887951 hasConcept C2780745239 @default.
- W2334887951 hasConcept C42219234 @default.
- W2334887951 hasConcept C46762472 @default.
- W2334887951 hasConcept C58245268 @default.
- W2334887951 hasConcept C71924100 @default.
- W2334887951 hasConcept C84393581 @default.
- W2334887951 hasConceptScore W2334887951C126322002 @default.
- W2334887951 hasConceptScore W2334887951C164705383 @default.
- W2334887951 hasConceptScore W2334887951C170493617 @default.
- W2334887951 hasConceptScore W2334887951C174940676 @default.
- W2334887951 hasConceptScore W2334887951C2776991684 @default.
- W2334887951 hasConceptScore W2334887951C2777032099 @default.
- W2334887951 hasConceptScore W2334887951C2778938600 @default.
- W2334887951 hasConceptScore W2334887951C2780745239 @default.
- W2334887951 hasConceptScore W2334887951C42219234 @default.
- W2334887951 hasConceptScore W2334887951C46762472 @default.
- W2334887951 hasConceptScore W2334887951C58245268 @default.
- W2334887951 hasConceptScore W2334887951C71924100 @default.
- W2334887951 hasConceptScore W2334887951C84393581 @default.
- W2334887951 hasIssue "12" @default.
- W2334887951 hasLocation W23348879511 @default.
- W2334887951 hasLocation W23348879512 @default.
- W2334887951 hasOpenAccess W2334887951 @default.
- W2334887951 hasPrimaryLocation W23348879511 @default.
- W2334887951 hasRelatedWork W1963939944 @default.
- W2334887951 hasRelatedWork W1990888000 @default.
- W2334887951 hasRelatedWork W1992495383 @default.
- W2334887951 hasRelatedWork W2037142508 @default.
- W2334887951 hasRelatedWork W2039691178 @default.
- W2334887951 hasRelatedWork W2084066876 @default.
- W2334887951 hasRelatedWork W2193587837 @default.
- W2334887951 hasRelatedWork W2334887951 @default.
- W2334887951 hasRelatedWork W2335149185 @default.
- W2334887951 hasRelatedWork W3143408161 @default.
- W2334887951 hasVolume "17" @default.
- W2334887951 isParatext "false" @default.
- W2334887951 isRetracted "false" @default.
- W2334887951 magId "2334887951" @default.
- W2334887951 workType "article" @default.