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- W2334894921 abstract "Anemia is common in patients with chronic renal insufficiency and secondary hyperparathyroidism. Erythropoietin therapy is effective, but the dose required varies greatly. One possible determinant of the efficacy of erythropoietin therapy is the extent of marrow fibrosis caused by hyperparathyroidism. We examined the relation between the erythropoietic response to erythropoietin and hyperparathyroidism in a cross-sectional study of 18 patients undergoing hemodialysis who had received erythropoietin therapy for one to three years. In 7 patients (the poor-response group) the dose of intravenous erythropoietin needed to maintain a mean (±SD) target hematocrit of 35 ±3 percent was >100 units per kilogram of body weight three times a week, and in 11 patients (the good-response group) it was ≤ 100 units per kilogram. In all patients, indexes of the adequacy of dialysis and the extent of hyperparathyroidism and aluminum toxicity were determined monthly, and bone histomorphometry was performed." @default.
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- W2334894921 date "1993-01-21" @default.
- W2334894921 modified "2023-10-17" @default.
- W2334894921 title "Effect of Serum Parathyroid Hormone and Bone Marrow Fibrosis on the Response to Erythropoietin in Uremia" @default.
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- W2334894921 doi "https://doi.org/10.1056/nejm199301213280304" @default.
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