FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334895944> ?p ?o ?g. }

• W2334895944 endingPage "991" @default.
• W2334895944 startingPage "982" @default.
• W2334895944 abstract "Human serum albumin (HSA) is the most abundant protein in plasma with a high ligand-binding capacity. This capacity impacts the pharmacokinetic properties of therapeutic drugs. In the present study, the binding properties of flutamide to HSA at different temperatures, pHs and percentages of HSA were investigated. Thermodynamic parameters were also determined to describe the nature of binding interaction. A modified ultrafiltration method was used for accurate determination of flutamide-HSA parameters. Ultra filtrate samples containing free flutamide were extracted and analyzed by developed HPLC-UV method. Analysis of binding data was performed in terms of Scatchard, Klotz and Hill plots. Kinetic parameters (n, Ka) were found to be affected by temperature, pH and HSA concentration. However, flutamide-HSA-binding level did not show significant differences under different experimental conditions. The negative value of Gibbs free energy (ΔG) indicated that the binding was spontaneous. Moreover, the negative value for enthalpy and entropy changes suggested that hydrogen bonding and van der Waals forces played major role in the binding of flutamide to HSA. The results suggested a positive cooperation behavior of flutamide-HSA-binding that was affected by pH, temperature and percentage of HSA." @default.
• W2334895944 created "2016-06-24" @default.
• W2334895944 creator A5003793995 @default.
• W2334895944 creator A5026152906 @default.
• W2334895944 creator A5029131650 @default.
• W2334895944 date "2016-04-07" @default.
• W2334895944 modified "2023-10-18" @default.
• W2334895944 title "The effects of pH, temperature and protein concentration on the<i>in vitro</i>binding of flutamide to human serum albumin" @default.
• W2334895944 cites W1481238172 @default.
• W2334895944 cites W1546615854 @default.
• W2334895944 cites W1575922693 @default.
• W2334895944 cites W1964754567 @default.
• W2334895944 cites W1983649348 @default.
• W2334895944 cites W1987327645 @default.
• W2334895944 cites W1991164277 @default.
• W2334895944 cites W1991834896 @default.
• W2334895944 cites W2005359245 @default.
• W2334895944 cites W2011373839 @default.
• W2334895944 cites W2014588537 @default.
• W2334895944 cites W2055072755 @default.
• W2334895944 cites W2056986090 @default.
• W2334895944 cites W2058183366 @default.
• W2334895944 cites W2059439459 @default.
• W2334895944 cites W2062656836 @default.
• W2334895944 cites W2065809987 @default.
• W2334895944 cites W2067763408 @default.
• W2334895944 cites W2075705506 @default.
• W2334895944 cites W2081646366 @default.
• W2334895944 cites W2090503901 @default.
• W2334895944 cites W2113272972 @default.
• W2334895944 cites W2139036288 @default.
• W2334895944 cites W2321075591 @default.
• W2334895944 doi "https://doi.org/10.3109/10837450.2016.1163392" @default.
• W2334895944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27055586" @default.
• W2334895944 hasPublicationYear "2016" @default.
• W2334895944 type Work @default.
• W2334895944 sameAs 2334895944 @default.
• W2334895944 citedByCount "11" @default.
• W2334895944 countsByYear W23348959442016 @default.
• W2334895944 countsByYear W23348959442019 @default.
• W2334895944 countsByYear W23348959442020 @default.
• W2334895944 countsByYear W23348959442021 @default.
• W2334895944 countsByYear W23348959442022 @default.
• W2334895944 crossrefType "journal-article" @default.
• W2334895944 hasAuthorship W2334895944A5003793995 @default.
• W2334895944 hasAuthorship W2334895944A5026152906 @default.
• W2334895944 hasAuthorship W2334895944A5029131650 @default.
• W2334895944 hasConcept C107824862 @default.
• W2334895944 hasConcept C121332964 @default.
• W2334895944 hasConcept C121608353 @default.
• W2334895944 hasConcept C126322002 @default.
• W2334895944 hasConcept C146477669 @default.
• W2334895944 hasConcept C185592680 @default.
• W2334895944 hasConcept C2778313021 @default.
• W2334895944 hasConcept C2778597219 @default.
• W2334895944 hasConcept C2780192828 @default.
• W2334895944 hasConcept C3288061 @default.
• W2334895944 hasConcept C43617362 @default.
• W2334895944 hasConcept C51639874 @default.
• W2334895944 hasConcept C55493867 @default.
• W2334895944 hasConcept C61367390 @default.
• W2334895944 hasConcept C71924100 @default.
• W2334895944 hasConcept C97355855 @default.
• W2334895944 hasConceptScore W2334895944C107824862 @default.
• W2334895944 hasConceptScore W2334895944C121332964 @default.
• W2334895944 hasConceptScore W2334895944C121608353 @default.
• W2334895944 hasConceptScore W2334895944C126322002 @default.
• W2334895944 hasConceptScore W2334895944C146477669 @default.
• W2334895944 hasConceptScore W2334895944C185592680 @default.
• W2334895944 hasConceptScore W2334895944C2778313021 @default.
• W2334895944 hasConceptScore W2334895944C2778597219 @default.
• W2334895944 hasConceptScore W2334895944C2780192828 @default.
• W2334895944 hasConceptScore W2334895944C3288061 @default.
• W2334895944 hasConceptScore W2334895944C43617362 @default.
• W2334895944 hasConceptScore W2334895944C51639874 @default.
• W2334895944 hasConceptScore W2334895944C55493867 @default.
• W2334895944 hasConceptScore W2334895944C61367390 @default.
• W2334895944 hasConceptScore W2334895944C71924100 @default.
• W2334895944 hasConceptScore W2334895944C97355855 @default.
• W2334895944 hasFunder F4320322587 @default.
• W2334895944 hasIssue "8" @default.
• W2334895944 hasLocation W23348959441 @default.
• W2334895944 hasLocation W23348959442 @default.
• W2334895944 hasOpenAccess W2334895944 @default.
• W2334895944 hasPrimaryLocation W23348959441 @default.
• W2334895944 hasRelatedWork W1569798034 @default.
• W2334895944 hasRelatedWork W1996253830 @default.
• W2334895944 hasRelatedWork W2004297424 @default.
• W2334895944 hasRelatedWork W2018370491 @default.
• W2334895944 hasRelatedWork W2039081785 @default.
• W2334895944 hasRelatedWork W2105898915 @default.
• W2334895944 hasRelatedWork W2890216081 @default.
• W2334895944 hasRelatedWork W4252787323 @default.
• W2334895944 hasRelatedWork W74915716 @default.
• W2334895944 hasRelatedWork W2741865982 @default.
• W2334895944 hasVolume "22" @default.
• W2334895944 isParatext "false" @default.
• W2334895944 isRetracted "false" @default.

• next