FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334962809> ?p ?o ?g. }

• W2334962809 endingPage "1021" @default.
• W2334962809 startingPage "1015" @default.
• W2334962809 abstract "In Brief Background Obesity promotes a state of low-grade inflammation that exacerbates chronic inflammatory diseases, such as asthma and inflammatory bowel disease. In transplantation, the survival of organs transplanted into obese patients is reduced compared with allografts in lean recipients. However, whether this is due to increased alloimmunity remains to be addressed conclusively. Methods We used a mouse model of high-fat diet (HFD)–induced obesity and assessed immune responses to allogeneic stimulation in vitro, allogeneic splenocyte immunization in vivo, and allogeneic heart transplantation. Results Our results indicate that HFD altered the composition and phenotype of splenic antigen-presenting cells that led to their enhanced capacity to stimulate T cells. Immunization with allogeneic splenocytes in vivo resulted in increased alloreactivity, as determined by IFNγ production. Moreover, cardiac allograft rejection in HFD mice was modestly accelerated compared to aged-matched control animals fed a low-fat diet, correlating with enhanced alloreactive T cell function. Conclusions Our results highlight the increased alloresponse triggered by HFD-induced obesity and its negative impact on transplant outcome. This article addresses whether high-fat, diet-induced obesity increases alloimmunity in mice. Obesity results in enhanced number and capacity of antigen-presenting cells to stimulate T cell proliferation and cytokine production. Obese mice reject cardiac allografts with faster kinetics than normal weight mice." @default.
• W2334962809 created "2016-06-24" @default.
• W2334962809 creator A5004584175 @default.
• W2334962809 creator A5018863416 @default.
• W2334962809 creator A5023053917 @default.
• W2334962809 creator A5044987508 @default.
• W2334962809 creator A5056037326 @default.
• W2334962809 creator A5085681006 @default.
• W2334962809 creator A5090706571 @default.
• W2334962809 date "2016-05-01" @default.
• W2334962809 modified "2023-10-11" @default.
• W2334962809 title "High-Fat Diet–Induced Obesity Enhances Allograft Rejection" @default.
• W2334962809 cites W1500808715 @default.
• W2334962809 cites W1521378499 @default.
• W2334962809 cites W1521515468 @default.
• W2334962809 cites W1570368653 @default.
• W2334962809 cites W1593575953 @default.
• W2334962809 cites W1884540304 @default.
• W2334962809 cites W1966372938 @default.
• W2334962809 cites W1970770095 @default.
• W2334962809 cites W1976513478 @default.
• W2334962809 cites W1980914602 @default.
• W2334962809 cites W1983869592 @default.
• W2334962809 cites W1985087591 @default.
• W2334962809 cites W1998689080 @default.
• W2334962809 cites W1998756277 @default.
• W2334962809 cites W2003449420 @default.
• W2334962809 cites W2003574906 @default.
• W2334962809 cites W2005801109 @default.
• W2334962809 cites W2015577339 @default.
• W2334962809 cites W2018192258 @default.
• W2334962809 cites W2023655124 @default.
• W2334962809 cites W2026591987 @default.
• W2334962809 cites W2028138973 @default.
• W2334962809 cites W2041457801 @default.
• W2334962809 cites W2048408076 @default.
• W2334962809 cites W2048546338 @default.
• W2334962809 cites W2064880478 @default.
• W2334962809 cites W2067846827 @default.
• W2334962809 cites W2071479447 @default.
• W2334962809 cites W2074014179 @default.
• W2334962809 cites W2080084246 @default.
• W2334962809 cites W2083102356 @default.
• W2334962809 cites W2092541959 @default.
• W2334962809 cites W2093726400 @default.
• W2334962809 cites W2099137703 @default.
• W2334962809 cites W2109302289 @default.
• W2334962809 cites W2139627403 @default.
• W2334962809 cites W2143903606 @default.
• W2334962809 cites W2156280702 @default.
• W2334962809 cites W2157217116 @default.
• W2334962809 cites W2160026116 @default.
• W2334962809 cites W2169534511 @default.
• W2334962809 cites W2171233986 @default.
• W2334962809 cites W2321611650 @default.
• W2334962809 cites W2328023807 @default.
• W2334962809 cites W2395472422 @default.
• W2334962809 cites W141955557 @default.
• W2334962809 doi "https://doi.org/10.1097/tp.0000000000001141" @default.
• W2334962809 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4846555" @default.
• W2334962809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27007226" @default.
• W2334962809 hasPublicationYear "2016" @default.
• W2334962809 type Work @default.
• W2334962809 sameAs 2334962809 @default.
• W2334962809 citedByCount "29" @default.
• W2334962809 countsByYear W23349628092016 @default.
• W2334962809 countsByYear W23349628092017 @default.
• W2334962809 countsByYear W23349628092018 @default.
• W2334962809 countsByYear W23349628092019 @default.
• W2334962809 countsByYear W23349628092020 @default.
• W2334962809 countsByYear W23349628092021 @default.
• W2334962809 countsByYear W23349628092022 @default.
• W2334962809 countsByYear W23349628092023 @default.
• W2334962809 crossrefType "journal-article" @default.
• W2334962809 hasAuthorship W2334962809A5004584175 @default.
• W2334962809 hasAuthorship W2334962809A5018863416 @default.
• W2334962809 hasAuthorship W2334962809A5023053917 @default.
• W2334962809 hasAuthorship W2334962809A5044987508 @default.
• W2334962809 hasAuthorship W2334962809A5056037326 @default.
• W2334962809 hasAuthorship W2334962809A5085681006 @default.
• W2334962809 hasAuthorship W2334962809A5090706571 @default.
• W2334962809 hasBestOaLocation W23349628092 @default.
• W2334962809 hasConcept C126322002 @default.
• W2334962809 hasConcept C134018914 @default.
• W2334962809 hasConcept C189976730 @default.
• W2334962809 hasConcept C203014093 @default.
• W2334962809 hasConcept C2776090121 @default.
• W2334962809 hasConcept C2776914184 @default.
• W2334962809 hasConcept C2778324207 @default.
• W2334962809 hasConcept C2778690821 @default.
• W2334962809 hasConcept C2911091166 @default.
• W2334962809 hasConcept C71924100 @default.
• W2334962809 hasConcept C8891405 @default.
• W2334962809 hasConceptScore W2334962809C126322002 @default.
• W2334962809 hasConceptScore W2334962809C134018914 @default.
• W2334962809 hasConceptScore W2334962809C189976730 @default.
• W2334962809 hasConceptScore W2334962809C203014093 @default.
• W2334962809 hasConceptScore W2334962809C2776090121 @default.

• next