FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334973379> ?p ?o ?g. }

• W2334973379 abstract "The clear cell/signet-ring cell variant of cutaneous squamous cell carcinoma (cSCC) is extremely rare. Its carcinogenesis has consistently been linked to ultraviolet radiation and HPV in the literature. However, there is little definite information about the contribution of diabetes mellitus (DM) to cSCC. A 78-year-old Chinese woman with type 2 DM presented with a mushroom-like lump in her right thigh. Histological findings revealed that the lesion was mainly composed of clear cells and signet-ring cells. The septa of vacuoles in cytoplasm displayed positivity for periodic acid schiff (PAS) and cytokeratins such as AE1/AE3, CK5/6, CK14, and CK19. Malignant cells did not express CK7, CK8, CK18, CK20, p16, p53, or c-erbB-2, and the Ki-67 index was less than 5 %. We further explored the etiology of clear cell/signet-ring cell cSCC using human papillomavirus (HPV) type-specific PCR and genotyping and confirmed that the patient was not infected with HPV. Nucleus positivity for p63 indicated the involvement of the p53 family in the lesion. Meanwhile, the expression of fibroblast growth factor receptor-2 (FGFR2), a downstream effector of p63, was upregulated in tumor cells. This study provides the first report on the clear cell/signet-ring cell variant of cSCC found in the right thigh of a patient with type 2 DM. Metabolic imbalance in addition to conventional pathogens such as UV and HPV may contribute to the development of the lesion via p63/FGFR2 axis." @default.
• W2334973379 created "2016-06-24" @default.
• W2334973379 creator A5006838194 @default.
• W2334973379 creator A5013066251 @default.
• W2334973379 creator A5014362347 @default.
• W2334973379 creator A5017956455 @default.
• W2334973379 creator A5020727273 @default.
• W2334973379 creator A5030698564 @default.
• W2334973379 creator A5038172993 @default.
• W2334973379 creator A5043165377 @default.
• W2334973379 creator A5063157569 @default.
• W2334973379 creator A5063354846 @default.
• W2334973379 creator A5069522797 @default.
• W2334973379 creator A5070324790 @default.
• W2334973379 creator A5071145197 @default.
• W2334973379 creator A5071197554 @default.
• W2334973379 creator A5084116173 @default.
• W2334973379 creator A5084136063 @default.
• W2334973379 date "2016-04-11" @default.
• W2334973379 modified "2023-10-17" @default.
• W2334973379 title "Cutaneous clear cell/signet-ring cell squamous cell carcinoma arising in the right thigh of a patient with type 2 diabetes: combined morphologic, immunohistochemical, and etiologic analysis" @default.
• W2334973379 cites W1964373486 @default.
• W2334973379 cites W1966089785 @default.
• W2334973379 cites W1975388471 @default.
• W2334973379 cites W1976256853 @default.
• W2334973379 cites W1982668502 @default.
• W2334973379 cites W2010807493 @default.
• W2334973379 cites W2012898404 @default.
• W2334973379 cites W2018715070 @default.
• W2334973379 cites W2018849791 @default.
• W2334973379 cites W2022685047 @default.
• W2334973379 cites W2023237359 @default.
• W2334973379 cites W2023332224 @default.
• W2334973379 cites W2024186654 @default.
• W2334973379 cites W2035615604 @default.
• W2334973379 cites W2035898922 @default.
• W2334973379 cites W2039791872 @default.
• W2334973379 cites W2043975636 @default.
• W2334973379 cites W2067250130 @default.
• W2334973379 cites W2072396752 @default.
• W2334973379 cites W2076467034 @default.
• W2334973379 cites W2081324857 @default.
• W2334973379 cites W2087774787 @default.
• W2334973379 cites W2096478290 @default.
• W2334973379 cites W2100358697 @default.
• W2334973379 cites W2110881155 @default.
• W2334973379 cites W2112131001 @default.
• W2334973379 cites W2120760498 @default.
• W2334973379 cites W2135158322 @default.
• W2334973379 cites W2154864587 @default.
• W2334973379 cites W215907204 @default.
• W2334973379 cites W2160834646 @default.
• W2334973379 cites W2169214947 @default.
• W2334973379 cites W2170170424 @default.
• W2334973379 cites W2334052885 @default.
• W2334973379 cites W2441696330 @default.
• W2334973379 cites W86724761 @default.
• W2334973379 doi "https://doi.org/10.1186/s13000-016-0487-1" @default.
• W2334973379 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4827219" @default.
• W2334973379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27066782" @default.
• W2334973379 hasPublicationYear "2016" @default.
• W2334973379 type Work @default.
• W2334973379 sameAs 2334973379 @default.
• W2334973379 citedByCount "11" @default.
• W2334973379 countsByYear W23349733792017 @default.
• W2334973379 countsByYear W23349733792018 @default.
• W2334973379 countsByYear W23349733792019 @default.
• W2334973379 countsByYear W23349733792020 @default.
• W2334973379 countsByYear W23349733792023 @default.
• W2334973379 crossrefType "journal-article" @default.
• W2334973379 hasAuthorship W2334973379A5006838194 @default.
• W2334973379 hasAuthorship W2334973379A5013066251 @default.
• W2334973379 hasAuthorship W2334973379A5014362347 @default.
• W2334973379 hasAuthorship W2334973379A5017956455 @default.
• W2334973379 hasAuthorship W2334973379A5020727273 @default.
• W2334973379 hasAuthorship W2334973379A5030698564 @default.
• W2334973379 hasAuthorship W2334973379A5038172993 @default.
• W2334973379 hasAuthorship W2334973379A5043165377 @default.
• W2334973379 hasAuthorship W2334973379A5063157569 @default.
• W2334973379 hasAuthorship W2334973379A5063354846 @default.
• W2334973379 hasAuthorship W2334973379A5069522797 @default.
• W2334973379 hasAuthorship W2334973379A5070324790 @default.
• W2334973379 hasAuthorship W2334973379A5071145197 @default.
• W2334973379 hasAuthorship W2334973379A5071197554 @default.
• W2334973379 hasAuthorship W2334973379A5084116173 @default.
• W2334973379 hasAuthorship W2334973379A5084136063 @default.
• W2334973379 hasBestOaLocation W23349733791 @default.
• W2334973379 hasConcept C121608353 @default.
• W2334973379 hasConcept C126322002 @default.
• W2334973379 hasConcept C142724271 @default.
• W2334973379 hasConcept C1491633281 @default.
• W2334973379 hasConcept C189528381 @default.
• W2334973379 hasConcept C204232928 @default.
• W2334973379 hasConcept C2779012181 @default.
• W2334973379 hasConcept C2781182431 @default.
• W2334973379 hasConcept C54355233 @default.
• W2334973379 hasConcept C71924100 @default.
• W2334973379 hasConcept C86803240 @default.
• W2334973379 hasConceptScore W2334973379C121608353 @default.
• W2334973379 hasConceptScore W2334973379C126322002 @default.

• next