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- W2334973952 abstract "We treated 7 cases of Meniere's disease with an oral osmotic diuretic, isosorbide, at a dose of 90 ml per day for more than one year (mean: 31.7 months). One case suffered from bilateral Meniere's disease. The long-term administration of constant daily amounts of isosorbide attained good long-term results in vertigo but poor in hearing according to the criteria of the Japan Society for Equilibrium Research for Meniere's disease. The results were as follows: the administration of isosorbide completely controlled vertigo in 29% and improved it in 42%, however, hearing was unchanged in 71% and worsened in 29%. To see if long-term follow-up of Meniere's patients using electro-cochleogram (ECoG) is useful for determination of therapeutic effects of isosorbide and establishment of its effective medication protocol, we examined relation-ships between long-term results of oral medication of isosorbide and the medication-induced changes in dominant -SP of ECoG. All eight affected ears of seven cases showed dominant -SP at their first visit and half of them didn't show it anymore after the long-term medication. There was no significant relationship between normalization of ECoG findings and improvement of vertigo. These findings indicate that normalization of ECoG findings cannot be a good marker for determination of therapeutic effects of isosorbide or establishment of its effective medication protocol." @default.
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- W2334973952 date "2004-01-01" @default.
- W2334973952 modified "2023-09-24" @default.
- W2334973952 title "Effects of Long-term Treatment with Osmotic Diuretics on Symptoms and Electro-cochleogram in Meniere's Disease" @default.
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- W2334973952 doi "https://doi.org/10.3757/jser.63.237" @default.
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