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• W2334974725 abstract "Event Abstract Back to Event T Lymphocyte-mediated suppression of murine granulopoiesis by oral allergen pretreatment of sensitized/challenged mice Maria Ignez Gaspar-Elsas1*, Tulio Queto1, Ricardo Luz2, Bianca DeLuca1, Cassio Almeida2, Daniela Masid De Brito2, Renato Ferreira1, Priscila Cauduro2, Bruno Vieira1, 2 and Pedro Xavier-Elsas2 1 FIOCRUZ, Brazil 2 Universidade Federal do Rio de Janeiro, immunology, Brazil Oral ovalbumin pre-exposure (oral OVA) effectively prevents the subsequent allergic pulmonary inflammation in sensitized/challenged (S/C) mice, reducing lung eosinophil (Eos) infiltration. In OVA-S/C mice, eosinopoiesis is suppressed by a proapoptotic mechanism requiring iNOS and CD95L. The role of bone-marrow (BM) regulation by iNOS/CD95L in the effects of oral OVA, remains to be established. We examined oral OVA effects on granulopoiesis in S/C mice. BP-2, BALB/c and C57BL/6 wild-type (WT) mice, and mutants lacking CD95L, were given OVA in water, and S/C with OVA. Granulopoiesis was evaluated in liquid and semisolid BM cultures. Spleen T cells from oral OVA/S/C donors, or from S/C controls, were transferred to syngeneic recipients, which were subsequently S/C with OVA before evaluation of BM eosinopoiesis. Oral OVA/S/C BP-2 mice had significantly decreased, relative to oral Water controls: a) Eos numbers in BM; b) IL-5-stimulated eosinopoiesis and GM-CSF-stimulated neutropoiesis; c) GM-CSF-stimulated Eos colony formation; d) OVA-specific IgE. Oral OVA was effective in BM CD95L-deficient mice. The effects of oral OVA on BM Eos numbers were duplicated by transfer of splenic T cells from oral OVA/S/C donors to syngeneic recipients, which were subsequently S/C, demonstrating a novel regulatory effect of oral OVA-induced T cells on granulopoiesis. Acknowledgements CNPq-FAPERJ-CAPES. References Elsas, PX, Maximiano, ES, Vargaftig, BB, Elsas, MI. (2003). The effects of allergen and anti-allergic drugs on murine hemopoietic cells: moving targets, unusual mechanisms, and changing paradigms. Current Drug Targets - Inflammation & Allergy 2, 329-337. Gaspar Elsas, MI, Maximiano, ES, Joseph, D, Alves, L, Topilko, A, Vargaftig, BB, Xavier Elsas, P. (2000a). Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone-marrow from normal and allergic mice. Br J Pharmacol, 129, 1543-1552. Gaspar Elsas, MI, Joseph, D, Lintomen, L, Maximiano, ES, Bodstein, M, Xavier Elsas, P, Vargaftig, BB. (2000b). Murine myeloid progenitor responses to GM-CSF and eosinophil precursor responses to IL-5 represent distinct targets for downmodulation by prostaglandin E(2). Br J Pharmacol 130, 1362-1368. Jones, CP, Paula Neto, HA, Assreuy, J, Vargaftig, BB, Gaspar Elsas, MI, Elsas, PX. (2004). Prostaglandin E2 and dexamethasone regulate eosinophil differentiation and survival through a nitric oxide- and CD95-dependent pathway. Nitric Oxide 11, 184-93. Lintomen, L, Gaspar-Elsas, MI, Maximiano, ES, de Paula Neto, HA, Joseph, D, Vargaftig, BB, Elsas, PX. (2002). Allergenic sensitization prevents upregulation of haemopoiesis by cyclo-oxygenase inhibitors in mice. Br J Pharmacol 135, 1315 -1323. Ten, RM, Pease, RL, McKean, DJ, Bell, MP, Gleich, GJ. (1989). Molecular cloning of the human eosinophil peroxidase. Evidence for the existence of a peroxidase multigene family. J Exp Med 169, 1757–1769. Rodrigues, C. M., O.A. Martins-Filho, N.M. Vaz, C.R. Carvalho (2006). Systemic effects of oral tolerance on inflammation: mobilization of lymphocytes and bone marrow eosinopoiesis Immunology 117, 517–525. Gaspar Elsas MI, Joseph D, Elsas PX, Vargaftig BB. Rapid increase in bone-marrow eosinophil production and responses to eosinopoietic interleukins triggered by intranasal allergen challenge. Am J Respir Cell Mol Biol 1997; 17 (4):404–13. Keywords: allergy, tolerance, eosinophil, Hematopoiesis, mucosal immunity Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Adaptive Immunity Citation: Gaspar-Elsas M, Queto T, Luz R, DeLuca B, Almeida C, Masid De Brito D, Ferreira R, Cauduro P, Vieira B and Xavier-Elsas P (2013). T Lymphocyte-mediated suppression of murine granulopoiesis by oral allergen pretreatment of sensitized/challenged mice. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00129 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 10 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Maria Ignez Gaspar-Elsas, FIOCRUZ, Rio de Janeiro, Brazil, gasparelsas@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Maria Ignez Gaspar-Elsas Tulio Queto Ricardo Luz Bianca DeLuca Cassio Almeida Daniela Masid De Brito Renato Ferreira Priscila Cauduro Bruno Vieira Pedro Xavier-Elsas Google Maria Ignez Gaspar-Elsas Tulio Queto Ricardo Luz Bianca DeLuca Cassio Almeida Daniela Masid De Brito Renato Ferreira Priscila Cauduro Bruno Vieira Pedro Xavier-Elsas Google Scholar Maria Ignez Gaspar-Elsas Tulio Queto Ricardo Luz Bianca DeLuca Cassio Almeida Daniela Masid De Brito Renato Ferreira Priscila Cauduro Bruno Vieira Pedro Xavier-Elsas PubMed Maria Ignez Gaspar-Elsas Tulio Queto Ricardo Luz Bianca DeLuca Cassio Almeida Daniela Masid De Brito Renato Ferreira Priscila Cauduro Bruno Vieira Pedro Xavier-Elsas Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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