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- W2334985196 abstract "Several morphological abnormalities have been described in the bones of patients with renal failure. These include parathyroid osteopathy, osteomalacia, rickets and volumetric changes (osteosclerosis and osteoporosis). Some 63% of adult patients entering a dialysis programme have parathyroid osteopathy while 30”;, have osteomalacia. During chronic hacmodialysis these skeletal changes tend to worsen with time unless specific measures are taken to prevent such deterioration. Serum immunorcactive parathyroid hormone (PTH) rises as renal function deteriorates. There is a good correlation between serum PTH and parathyroid osteopathy in non-dialyzed and in dialyzed patients. Serum concentrations of 3 vitamin D metabolites. 25 hydroxyvilamin D (250HD), 24.25 dihydroxyvitamin D (24,25(OH) 2 D) correlate positively with one another and negatively with the severity of osteomalacia. On the other hand, the concentration of serum 1.25(OH) 2 D is not correlated with that of the other vitamin D metabolites or with the severity of osteomalacia but is negatively correlated with the severity of parathyroid osteopathy. After renal transplantation the bone lesions regress, serum PTH falls and serum vitamin D values rise. Mild serum PTH elevation and parathyroid osteopathy may persist for years." @default.
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- W2334985196 date "1981-01-01" @default.
- W2334985196 modified "2023-09-27" @default.
- W2334985196 title "Renal bone disease" @default.
- W2334985196 doi "https://doi.org/10.1016/s0031-3025(16)38423-9" @default.
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