FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2335011054> ?p ?o ?g. }

• W2335011054 endingPage "7991" @default.
• W2335011054 startingPage "7986" @default.
• W2335011054 abstract "Nitriles, amides and carboxylic acids have varied applications in active pharmaceutical intermediate (API), drug and chemical industry, and particularly in the synthesis of pure enantiomers of chiral compounds. The chemical hydrolysis of nitrile compounds is well studied, but it necessitates harsh conditions along with the protection of sensitive functional groups, which on deprotection leads to generation of a large amount of byproducts. Immobilization of nitrile hydratase using a novel support reduces the cost and allows green processes. In this work, enantioselective hydrolysis of rac-mandelonitrile was studied using poly(vinyl alcohol) (PVA)/chitosan–glutaraldehyde cross-linked Rhodococcus rhodochrous ATCC BAA-870 nitrile hydratase (NHase). Immobilized NHase converted rac-mandelonitrile to (R)-amide by dynamic kinetic resolution with enantiomeric excess (ee) up to 81%. The temperature of 40 °C and pH 8 were found to be optimum for the enantioselective nitrile hydrolysis. In the presence of various cosolvents, immobilized NHase showed higher retention of activity in methanol compared to other cosolvents. The kinetic constants for free and immobilized enzyme were obtained from the Lineweaver–Burk plot. The immobilized NHase was found to be reusable up to nine successive batch reactions." @default.
• W2335011054 created "2016-06-24" @default.
• W2335011054 creator A5059492859 @default.
• W2335011054 creator A5063648631 @default.
• W2335011054 date "2014-04-25" @default.
• W2335011054 modified "2023-10-14" @default.
• W2335011054 title "Enantioselective Enzymatic Hydrolysis of <i>rac-</i>Mandelonitrile to <i>R</i>-Mandelamide by Nitrile Hydratase Immobilized on Poly(vinyl alcohol)/Chitosan–Glutaraldehyde Support" @default.
• W2335011054 cites W1965582163 @default.
• W2335011054 cites W1967779445 @default.
• W2335011054 cites W1970545344 @default.
• W2335011054 cites W1971619029 @default.
• W2335011054 cites W1971627029 @default.
• W2335011054 cites W1973953717 @default.
• W2335011054 cites W1973958979 @default.
• W2335011054 cites W1978668078 @default.
• W2335011054 cites W1980110880 @default.
• W2335011054 cites W1987830038 @default.
• W2335011054 cites W1997358405 @default.
• W2335011054 cites W2006925160 @default.
• W2335011054 cites W2007062211 @default.
• W2335011054 cites W2014029667 @default.
• W2335011054 cites W2017813058 @default.
• W2335011054 cites W2024914551 @default.
• W2335011054 cites W2030640884 @default.
• W2335011054 cites W2039923245 @default.
• W2335011054 cites W2055667713 @default.
• W2335011054 cites W2059571565 @default.
• W2335011054 cites W2066048433 @default.
• W2335011054 cites W2067270459 @default.
• W2335011054 cites W2076046354 @default.
• W2335011054 cites W2079372771 @default.
• W2335011054 cites W2091127965 @default.
• W2335011054 cites W2112794825 @default.
• W2335011054 cites W2200500088 @default.
• W2335011054 cites W2332336273 @default.
• W2335011054 cites W3023866328 @default.
• W2335011054 cites W4242865746 @default.
• W2335011054 doi "https://doi.org/10.1021/ie500564b" @default.
• W2335011054 hasPublicationYear "2014" @default.
• W2335011054 type Work @default.
• W2335011054 sameAs 2335011054 @default.
• W2335011054 citedByCount "26" @default.
• W2335011054 countsByYear W23350110542014 @default.
• W2335011054 countsByYear W23350110542015 @default.
• W2335011054 countsByYear W23350110542017 @default.
• W2335011054 countsByYear W23350110542018 @default.
• W2335011054 countsByYear W23350110542019 @default.
• W2335011054 countsByYear W23350110542020 @default.
• W2335011054 countsByYear W23350110542021 @default.
• W2335011054 countsByYear W23350110542022 @default.
• W2335011054 crossrefType "journal-article" @default.
• W2335011054 hasAuthorship W2335011054A5059492859 @default.
• W2335011054 hasAuthorship W2335011054A5063648631 @default.
• W2335011054 hasConcept C146686406 @default.
• W2335011054 hasConcept C161790260 @default.
• W2335011054 hasConcept C178790620 @default.
• W2335011054 hasConcept C181199279 @default.
• W2335011054 hasConcept C185592680 @default.
• W2335011054 hasConcept C2777529624 @default.
• W2335011054 hasConcept C2778439535 @default.
• W2335011054 hasConcept C2779122190 @default.
• W2335011054 hasConcept C2779240715 @default.
• W2335011054 hasConcept C2779732960 @default.
• W2335011054 hasConcept C2779952263 @default.
• W2335011054 hasConcept C2780666587 @default.
• W2335011054 hasConcept C2781246646 @default.
• W2335011054 hasConcept C28173026 @default.
• W2335011054 hasConcept C33633552 @default.
• W2335011054 hasConcept C486523 @default.
• W2335011054 hasConcept C521977710 @default.
• W2335011054 hasConcept C65588867 @default.
• W2335011054 hasConcept C94412978 @default.
• W2335011054 hasConceptScore W2335011054C146686406 @default.
• W2335011054 hasConceptScore W2335011054C161790260 @default.
• W2335011054 hasConceptScore W2335011054C178790620 @default.
• W2335011054 hasConceptScore W2335011054C181199279 @default.
• W2335011054 hasConceptScore W2335011054C185592680 @default.
• W2335011054 hasConceptScore W2335011054C2777529624 @default.
• W2335011054 hasConceptScore W2335011054C2778439535 @default.
• W2335011054 hasConceptScore W2335011054C2779122190 @default.
• W2335011054 hasConceptScore W2335011054C2779240715 @default.
• W2335011054 hasConceptScore W2335011054C2779732960 @default.
• W2335011054 hasConceptScore W2335011054C2779952263 @default.
• W2335011054 hasConceptScore W2335011054C2780666587 @default.
• W2335011054 hasConceptScore W2335011054C2781246646 @default.
• W2335011054 hasConceptScore W2335011054C28173026 @default.
• W2335011054 hasConceptScore W2335011054C33633552 @default.
• W2335011054 hasConceptScore W2335011054C486523 @default.
• W2335011054 hasConceptScore W2335011054C521977710 @default.
• W2335011054 hasConceptScore W2335011054C65588867 @default.
• W2335011054 hasConceptScore W2335011054C94412978 @default.
• W2335011054 hasIssue "19" @default.
• W2335011054 hasLocation W23350110541 @default.
• W2335011054 hasOpenAccess W2335011054 @default.
• W2335011054 hasPrimaryLocation W23350110541 @default.
• W2335011054 hasRelatedWork W1988644775 @default.
• W2335011054 hasRelatedWork W1990932627 @default.
• W2335011054 hasRelatedWork W1992560252 @default.

• next