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• W2335048553 abstract "The immobilization of oligonucleotide sequences onto glass supports is central to the field of biodiagnostics and molecular biology with the widespread use of DNA microarrays. However, the influence of confinement on the behavior of DNA immobilized on silica is not well understood owing to the difficulties associated with monitoring this buried interface. Second harmonic generation (SHG) is an inherently surface specific technique making it well suited to observe processes at insulator interfaces like silica. Using a universal 3-nitropyrolle nucleotide as an SHG-active label, we monitored the hybridization rate and thermal dissociation of a 15-mer of DNA immobilized at the silica/aqueous interface. The immobilized DNA exhibits hybridization rates on the minute time scale, which is much slower than hybridization kinetics in solution but on par with hybridization behavior observed at electrochemical interfaces. In contrast, the thermal dissociation temperature of the DNA immobilized on silica is on average 12 °C lower than the analogous duplex in solution, which is more significant than that observed on other surfaces like gold. We attribute the destabilizing affect of silica to its negatively charged surface at neutral pH that repels the hybridizing complementary DNA." @default.
• W2335048553 created "2016-06-24" @default.
• W2335048553 creator A5031994881 @default.
• W2335048553 creator A5063832532 @default.
• W2335048553 date "2013-08-22" @default.
• W2335048553 modified "2023-10-16" @default.
• W2335048553 title "Monitoring DNA Hybridization and Thermal Dissociation at the Silica/Water Interface Using Resonantly Enhanced Second Harmonic Generation Spectroscopy" @default.
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• W2335048553 doi "https://doi.org/10.1021/ac401009u" @default.
• W2335048553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23927789" @default.
• W2335048553 hasPublicationYear "2013" @default.
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