Matches in SemOpenAlex for { <https://semopenalex.org/work/W2335101889> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2335101889 abstract "While anti-inflammatory therapies are being evaluated in lung cancer, the role of specific immune effector cells and their products in lung carcinogenesis is unclear. Alveolar macrophage numbers increase as lung tumors progress, and subsequent changes in macrophage function are linked to increased growth factor production, accelerated tumor proliferation, enhanced angiogenesis, depressed immune response, and metastasis. However, the signaling molecules linking alveolar macrophages to advanced lung tumor growth are not well defined. To examine how macrophages drive lung tumorigenesis, clodronate-encapsulated liposomes were used to specifically deplete alveolar macrophages in mice bearing chemically-induced lung tumors. Treatment efficacy was assessed by evaluating tumor burden, multiplicity, proliferation index and histologic stage. Alveolar macrophage populations decreased to ≤ 50% of control levels during six weeks of liposomal clodronate treatment. This was associated with significantly decreased pulmonary levels of IGF-1, KC, IL-6 and CCL2. The concentrations of these cytokines strongly correlated with decreased macrophage numbers in lung lavage fluid. Tumor burden and Ki-67 index was reduced by 50% in clodronate-treated mice, corresponding with the 50% decrease in macrophage numbers and cytokine content. Therefore, macrophage depletion attenuates lung tumor proliferation in vivo, consistent with our previous observations linking macrophage IGF-1 production and lung tumor proliferation in vitro. These cytokines appear to mediate macrophage-stimulated lung tumorigenesis, and are thus potential therapeutic targets in lung cancer and chronic inflammatory lung disease. Citation Format: Jason Fritz, Meredith A. Tennis, Alvin Malkinson, Lori Dwyer-Nield. Alveolar macrophage depletion decreases lung cytokines and decreases mouse lung tumor growth. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1530. doi:10.1158/1538-7445.AM2013-1530" @default.
- W2335101889 created "2016-06-24" @default.
- W2335101889 creator A5017931672 @default.
- W2335101889 creator A5053252425 @default.
- W2335101889 creator A5066678557 @default.
- W2335101889 creator A5085283368 @default.
- W2335101889 date "2013-04-15" @default.
- W2335101889 modified "2023-09-27" @default.
- W2335101889 title "Abstract 1530: Alveolar macrophage depletion decreases lung cytokines and decreases mouse lung tumor growth." @default.
- W2335101889 doi "https://doi.org/10.1158/1538-7445.am2013-1530" @default.
- W2335101889 hasPublicationYear "2013" @default.
- W2335101889 type Work @default.
- W2335101889 sameAs 2335101889 @default.
- W2335101889 citedByCount "0" @default.
- W2335101889 crossrefType "proceedings-article" @default.
- W2335101889 hasAuthorship W2335101889A5017931672 @default.
- W2335101889 hasAuthorship W2335101889A5053252425 @default.
- W2335101889 hasAuthorship W2335101889A5066678557 @default.
- W2335101889 hasAuthorship W2335101889A5085283368 @default.
- W2335101889 hasConcept C101666144 @default.
- W2335101889 hasConcept C121608353 @default.
- W2335101889 hasConcept C126322002 @default.
- W2335101889 hasConcept C13373296 @default.
- W2335101889 hasConcept C142724271 @default.
- W2335101889 hasConcept C164027704 @default.
- W2335101889 hasConcept C185592680 @default.
- W2335101889 hasConcept C202751555 @default.
- W2335101889 hasConcept C203014093 @default.
- W2335101889 hasConcept C2776256026 @default.
- W2335101889 hasConcept C2776914184 @default.
- W2335101889 hasConcept C2777714996 @default.
- W2335101889 hasConcept C2778012055 @default.
- W2335101889 hasConcept C2778690821 @default.
- W2335101889 hasConcept C2779244956 @default.
- W2335101889 hasConcept C502942594 @default.
- W2335101889 hasConcept C55493867 @default.
- W2335101889 hasConcept C555283112 @default.
- W2335101889 hasConcept C71924100 @default.
- W2335101889 hasConcept C8891405 @default.
- W2335101889 hasConceptScore W2335101889C101666144 @default.
- W2335101889 hasConceptScore W2335101889C121608353 @default.
- W2335101889 hasConceptScore W2335101889C126322002 @default.
- W2335101889 hasConceptScore W2335101889C13373296 @default.
- W2335101889 hasConceptScore W2335101889C142724271 @default.
- W2335101889 hasConceptScore W2335101889C164027704 @default.
- W2335101889 hasConceptScore W2335101889C185592680 @default.
- W2335101889 hasConceptScore W2335101889C202751555 @default.
- W2335101889 hasConceptScore W2335101889C203014093 @default.
- W2335101889 hasConceptScore W2335101889C2776256026 @default.
- W2335101889 hasConceptScore W2335101889C2776914184 @default.
- W2335101889 hasConceptScore W2335101889C2777714996 @default.
- W2335101889 hasConceptScore W2335101889C2778012055 @default.
- W2335101889 hasConceptScore W2335101889C2778690821 @default.
- W2335101889 hasConceptScore W2335101889C2779244956 @default.
- W2335101889 hasConceptScore W2335101889C502942594 @default.
- W2335101889 hasConceptScore W2335101889C55493867 @default.
- W2335101889 hasConceptScore W2335101889C555283112 @default.
- W2335101889 hasConceptScore W2335101889C71924100 @default.
- W2335101889 hasConceptScore W2335101889C8891405 @default.
- W2335101889 hasLocation W23351018891 @default.
- W2335101889 hasOpenAccess W2335101889 @default.
- W2335101889 hasPrimaryLocation W23351018891 @default.
- W2335101889 hasRelatedWork W1905193706 @default.
- W2335101889 hasRelatedWork W1985855344 @default.
- W2335101889 hasRelatedWork W1988689331 @default.
- W2335101889 hasRelatedWork W2062502136 @default.
- W2335101889 hasRelatedWork W2074598971 @default.
- W2335101889 hasRelatedWork W2078215254 @default.
- W2335101889 hasRelatedWork W2085009992 @default.
- W2335101889 hasRelatedWork W2123022215 @default.
- W2335101889 hasRelatedWork W2195011242 @default.
- W2335101889 hasRelatedWork W2462992958 @default.
- W2335101889 hasRelatedWork W2515980396 @default.
- W2335101889 hasRelatedWork W2529369348 @default.
- W2335101889 hasRelatedWork W2560597144 @default.
- W2335101889 hasRelatedWork W2561518237 @default.
- W2335101889 hasRelatedWork W2793866905 @default.
- W2335101889 hasRelatedWork W2894620151 @default.
- W2335101889 hasRelatedWork W2927129951 @default.
- W2335101889 hasRelatedWork W3012312272 @default.
- W2335101889 hasRelatedWork W3083162995 @default.
- W2335101889 hasRelatedWork W3212682569 @default.
- W2335101889 isParatext "false" @default.
- W2335101889 isRetracted "false" @default.
- W2335101889 magId "2335101889" @default.
- W2335101889 workType "article" @default.