FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2335124013> ?p ?o ?g. }

• W2335124013 endingPage "36" @default.
• W2335124013 startingPage "32" @default.
• W2335124013 abstract "We investigated if gene copy number (GCN) alterations of the epidermal growth factor receptor (EGFR), as detected by silver enhanced in situ hybridisation (SISH), could be used to select patients for EGFR mutation testing. Resected lung adenocarcinoma specimens with adequate tumour were identified. EGFR SISH was performed using the Ventana Benchmark Ultra platform. EGFR GCN was classified according to the Colorado Classification System. EGFR mutations were scanned by high resolution melting and confirmed by Sanger sequencing. Thirty-four of 96 tumours were EGFR SISH positive (35%), and 31 of 96 tumours harboured one or more EGFR mutations (32%). Of 31 EGFR-mutant tumours, 18 were EGFR SISH positive (58%). There was a statistically significant relationship between the presence of an EGFR mutation and EGFR GCN (p = 0.003). Thirteen of 31 EGFR-mutant tumours were EGFR SISH negative (42%), and 16 of 65 EGFR-wild type tumours were EGFR SISH positive (24%). The sensitivity, specificity, positive predictive value and negative predictive value were 58%, 75%, 52.9% and 79%, respectively. Despite a significant relationship between EGFR GCN alterations and EGFR mutations, our results indicate that EGFR GCN as detected by SISH is not a suitable way to select patients for EGFR mutation testing. We investigated if gene copy number (GCN) alterations of the epidermal growth factor receptor (EGFR), as detected by silver enhanced in situ hybridisation (SISH), could be used to select patients for EGFR mutation testing. Resected lung adenocarcinoma specimens with adequate tumour were identified. EGFR SISH was performed using the Ventana Benchmark Ultra platform. EGFR GCN was classified according to the Colorado Classification System. EGFR mutations were scanned by high resolution melting and confirmed by Sanger sequencing. Thirty-four of 96 tumours were EGFR SISH positive (35%), and 31 of 96 tumours harboured one or more EGFR mutations (32%). Of 31 EGFR-mutant tumours, 18 were EGFR SISH positive (58%). There was a statistically significant relationship between the presence of an EGFR mutation and EGFR GCN (p = 0.003). Thirteen of 31 EGFR-mutant tumours were EGFR SISH negative (42%), and 16 of 65 EGFR-wild type tumours were EGFR SISH positive (24%). The sensitivity, specificity, positive predictive value and negative predictive value were 58%, 75%, 52.9% and 79%, respectively. Despite a significant relationship between EGFR GCN alterations and EGFR mutations, our results indicate that EGFR GCN as detected by SISH is not a suitable way to select patients for EGFR mutation testing." @default.
• W2335124013 created "2016-06-24" @default.
• W2335124013 creator A5014099292 @default.
• W2335124013 creator A5022581320 @default.
• W2335124013 creator A5024162410 @default.
• W2335124013 creator A5026688966 @default.
• W2335124013 creator A5035871654 @default.
• W2335124013 creator A5042977767 @default.
• W2335124013 creator A5049046883 @default.
• W2335124013 creator A5060453465 @default.
• W2335124013 creator A5067030352 @default.
• W2335124013 creator A5068654488 @default.
• W2335124013 date "2014-01-01" @default.
• W2335124013 modified "2023-09-24" @default.
• W2335124013 title "EGFR gene copy number alterations are not a useful screening tool for predicting EGFR mutation status in lung adenocarcinoma" @default.
• W2335124013 cites W1525027209 @default.
• W2335124013 cites W1970476748 @default.
• W2335124013 cites W1971099024 @default.
• W2335124013 cites W1984236111 @default.
• W2335124013 cites W1988442083 @default.
• W2335124013 cites W1995703033 @default.
• W2335124013 cites W1995907876 @default.
• W2335124013 cites W2024893266 @default.
• W2335124013 cites W2032861637 @default.
• W2335124013 cites W2036189924 @default.
• W2335124013 cites W2037370208 @default.
• W2335124013 cites W2049674541 @default.
• W2335124013 cites W2059761764 @default.
• W2335124013 cites W2068403104 @default.
• W2335124013 cites W2091077474 @default.
• W2335124013 cites W2107304950 @default.
• W2335124013 cites W2111662961 @default.
• W2335124013 cites W2113843552 @default.
• W2335124013 cites W2129360604 @default.
• W2335124013 cites W2129868701 @default.
• W2335124013 cites W2132157071 @default.
• W2335124013 cites W2146909958 @default.
• W2335124013 cites W2154662831 @default.
• W2335124013 cites W2160866033 @default.
• W2335124013 cites W2160982674 @default.
• W2335124013 cites W2166084034 @default.
• W2335124013 cites W2167789193 @default.
• W2335124013 doi "https://doi.org/10.1097/pat.0000000000000027" @default.
• W2335124013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24300726" @default.
• W2335124013 hasPublicationYear "2014" @default.
• W2335124013 type Work @default.
• W2335124013 sameAs 2335124013 @default.
• W2335124013 citedByCount "0" @default.
• W2335124013 crossrefType "journal-article" @default.
• W2335124013 hasAuthorship W2335124013A5014099292 @default.
• W2335124013 hasAuthorship W2335124013A5022581320 @default.
• W2335124013 hasAuthorship W2335124013A5024162410 @default.
• W2335124013 hasAuthorship W2335124013A5026688966 @default.
• W2335124013 hasAuthorship W2335124013A5035871654 @default.
• W2335124013 hasAuthorship W2335124013A5042977767 @default.
• W2335124013 hasAuthorship W2335124013A5049046883 @default.
• W2335124013 hasAuthorship W2335124013A5060453465 @default.
• W2335124013 hasAuthorship W2335124013A5067030352 @default.
• W2335124013 hasAuthorship W2335124013A5068654488 @default.
• W2335124013 hasConcept C104317684 @default.
• W2335124013 hasConcept C120821319 @default.
• W2335124013 hasConcept C121608353 @default.
• W2335124013 hasConcept C126322002 @default.
• W2335124013 hasConcept C141231307 @default.
• W2335124013 hasConcept C142724271 @default.
• W2335124013 hasConcept C143065580 @default.
• W2335124013 hasConcept C2776256026 @default.
• W2335124013 hasConcept C2777506169 @default.
• W2335124013 hasConcept C2779438470 @default.
• W2335124013 hasConcept C2781182431 @default.
• W2335124013 hasConcept C2994225774 @default.
• W2335124013 hasConcept C34372108 @default.
• W2335124013 hasConcept C49105822 @default.
• W2335124013 hasConcept C501734568 @default.
• W2335124013 hasConcept C502942594 @default.
• W2335124013 hasConcept C54355233 @default.
• W2335124013 hasConcept C71924100 @default.
• W2335124013 hasConcept C86803240 @default.
• W2335124013 hasConceptScore W2335124013C104317684 @default.
• W2335124013 hasConceptScore W2335124013C120821319 @default.
• W2335124013 hasConceptScore W2335124013C121608353 @default.
• W2335124013 hasConceptScore W2335124013C126322002 @default.
• W2335124013 hasConceptScore W2335124013C141231307 @default.
• W2335124013 hasConceptScore W2335124013C142724271 @default.
• W2335124013 hasConceptScore W2335124013C143065580 @default.
• W2335124013 hasConceptScore W2335124013C2776256026 @default.
• W2335124013 hasConceptScore W2335124013C2777506169 @default.
• W2335124013 hasConceptScore W2335124013C2779438470 @default.
• W2335124013 hasConceptScore W2335124013C2781182431 @default.
• W2335124013 hasConceptScore W2335124013C2994225774 @default.
• W2335124013 hasConceptScore W2335124013C34372108 @default.
• W2335124013 hasConceptScore W2335124013C49105822 @default.
• W2335124013 hasConceptScore W2335124013C501734568 @default.
• W2335124013 hasConceptScore W2335124013C502942594 @default.
• W2335124013 hasConceptScore W2335124013C54355233 @default.
• W2335124013 hasConceptScore W2335124013C71924100 @default.
• W2335124013 hasConceptScore W2335124013C86803240 @default.
• W2335124013 hasIssue "1" @default.

• next