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• W2335149957 startingPage "197" @default.
• W2335149957 abstract "Objective This study tests the hypothesis that elevated levels of rest myocardial blood flow (MBF), indicative of inefficient aerobic metabolism, will be present in some patients with mitochondrial disorders but structurally normal hearts. Background Regulation of MBF is a complex process closely linked to myocardial energy production. Aerobic metabolism in turn depends on normal mitochondrial function and so investigation of patients with mitochondrial disorders may provide important information regarding heritable mechanisms involved in regulation of myocardial flow. Methods Rest and adenosine-stimulated MBF was measured by the positron emission tomography (PET) 13NH3 technique in nine patients with mitochondrial disorders and compared with 15 age-matched control participants. Results Basal heart rate (beats/min) and rate pressure product (mmHg/min) were elevated in patients (76 ± 13 and 9302 ± 1910, mean± SD, respectively) compared with control participants (63 ± 9 and 7411 ± 1531, P < 0.01 and P <0.05, respectively). However, rest and adenosine-stimulated MBF (ml/min per g) did not differ significantly between groups (patients, 1.13 ± 0.52 and 4.17 ± 0.84, respectively; control participants, 0.85 ± 0.30 and 3.56 ± 0.63, respectively). Normalization of rest MBF to rate pressure product, however, demonstrated three patients whose values exceeded that of all control participants (χ2 = 5.71, P< 0.05, Fisher's exact test). Conclusions Elevated basal MBF, in some patients with mitochondrial disorders but structurally normal hearts, suggests the level of basal flow is responsive to efficiency of aerobic metabolism, which closely reflects mitochondrial function. Mitochondrial heteroplasmy with relative sparing of myocardial mitochondria may account for normal basal flow in others with these disorders.Coron Artery Dis14:197-205 © 2003 Lippincott Williams & Wilkins." @default.
• W2335149957 created "2016-06-24" @default.
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• W2335149957 date "2003-05-01" @default.
• W2335149957 modified "2023-09-26" @default.
• W2335149957 title "Myocardial flow regulation in people with mitochondrial myopathy, encephalopathy, lactic acidosis, stroke-like episodes/myoclonic epilepsy and ragged red fibers and other mitochondrial syndromes" @default.
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• W2335149957 doi "https://doi.org/10.1097/01.mca.0000065743.52558.51" @default.
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