FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2335202390> ?p ?o ?g. }

• W2335202390 abstract "You have accessJournal of UrologyProstate Cancer: Localized VII1 Apr 20121476 EFFECT OF SALVAGE RADIOTHERAPY FOR THE PATIENTS ON BIOCHEMICAL PROGRESSION AND CANCER-SPECIFIC SURVIVAL Kiyotugu Hoshi, Natuho Hayashi, Yuuta Kurota, Akinori Muto, Kenji Numahata, Osamu Sugano, and Senji Hoshi Kiyotugu HoshiKiyotugu Hoshi Yamagata, Japan More articles by this author , Natuho HayashiNatuho Hayashi Yamagata, Japan More articles by this author , Yuuta KurotaYuuta Kurota Yamagata, Japan More articles by this author , Akinori MutoAkinori Muto Yamagata, Japan More articles by this author , Kenji NumahataKenji Numahata Yamagata, Japan More articles by this author , Osamu SuganoOsamu Sugano Yamagata, Japan More articles by this author , and Senji HoshiSenji Hoshi Yamagata, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1997AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Prospective, randomized trials have shown a significant impact of adjuvant radiation therapy (RT) on biochemical progression (BCR) in patients with locally advanced prostate cancer (PCa) at radical prostatectomy (RP). However, the prognosis of patients who experienced BCR after adjuvant RT has not been extensively investigated. METHODS The study included 79 consecutive patients treated with RP, pelvic lymph node dissection and adjuvant RT for locally advanced PCa (pT3a/pT3b) and/or positive surgical margins (SM+) between 1988 and 2006 at a single cancer center in Japan. All patients had complete pathological data (including pathological stage and Gleason sum at RP, lymph node and surgical margin status). All patients experienced BCR (defined as two consecutive PSA values>0.2 ng/ml) after adjuvant RT. The Kaplan Meier method explored time to cancer-specific mortality (CSM). Univariable and multivariable Cox regression models tested the association between predictors (namely, pre-operative PSA, pathological Gleason sum and stage, time to BCR) and CSM. RESULTS Mean and median age at BCR were 65 and 65.3 yrs, respectively. Mean and median PSA at surgery were 26 and 14.7 ng/ml, respectively. RP Gleason sum was 6, 7 and 8-10 in 22.4, 37.9 and 39.7% of patients, respectively. Extracapsular extension and seminal vesicle invasion (SVI) were present in 81.5 and 18.5% of patients, respectively. Overall, 52.2% of patients had SM+. At Kaplan Meier analysis, cancer specific survival rates at 5 10 and 15 years after BCR were 96, 96 and 78%, respectively. At univariable analyses, age, PSA, RP Gleason sum, SVI, LNI and time to BCR were significantly associated with higher rates of CSM. At multivariable analyses, after adjusting for age, RP Gleason sum, the presence of LNI represented the independent predictors of CSM. CONCLUSIONS Not all patients experiencing BCR after RP and adjuvant RT have the same survival outcome. In case of failure after adjuvant RT, RP Gleason sum and the presence of LNI at RP were significantly associated with higher rates of CSM. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e598-e599 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kiyotugu Hoshi Yamagata, Japan More articles by this author Natuho Hayashi Yamagata, Japan More articles by this author Yuuta Kurota Yamagata, Japan More articles by this author Akinori Muto Yamagata, Japan More articles by this author Kenji Numahata Yamagata, Japan More articles by this author Osamu Sugano Yamagata, Japan More articles by this author Senji Hoshi Yamagata, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
• W2335202390 created "2016-06-24" @default.
• W2335202390 creator A5000010469 @default.
• W2335202390 creator A5000788271 @default.
• W2335202390 creator A5034578106 @default.
• W2335202390 creator A5040615047 @default.
• W2335202390 creator A5043742168 @default.
• W2335202390 creator A5061532693 @default.
• W2335202390 creator A5070733336 @default.
• W2335202390 date "2012-04-01" @default.
• W2335202390 modified "2023-09-25" @default.
• W2335202390 title "1476 EFFECT OF SALVAGE RADIOTHERAPY FOR THE PATIENTS ON BIOCHEMICAL PROGRESSION AND CANCER-SPECIFIC SURVIVAL" @default.
• W2335202390 doi "https://doi.org/10.1016/j.juro.2012.02.1997" @default.
• W2335202390 hasPublicationYear "2012" @default.
• W2335202390 type Work @default.
• W2335202390 sameAs 2335202390 @default.
• W2335202390 citedByCount "0" @default.
• W2335202390 crossrefType "journal-article" @default.
• W2335202390 hasAuthorship W2335202390A5000010469 @default.
• W2335202390 hasAuthorship W2335202390A5000788271 @default.
• W2335202390 hasAuthorship W2335202390A5034578106 @default.
• W2335202390 hasAuthorship W2335202390A5040615047 @default.
• W2335202390 hasAuthorship W2335202390A5043742168 @default.
• W2335202390 hasAuthorship W2335202390A5061532693 @default.
• W2335202390 hasAuthorship W2335202390A5070733336 @default.
• W2335202390 hasConcept C121608353 @default.
• W2335202390 hasConcept C126322002 @default.
• W2335202390 hasConcept C126894567 @default.
• W2335202390 hasConcept C141071460 @default.
• W2335202390 hasConcept C143998085 @default.
• W2335202390 hasConcept C2775862295 @default.
• W2335202390 hasConcept C2777008409 @default.
• W2335202390 hasConcept C2779466945 @default.
• W2335202390 hasConcept C2780192828 @default.
• W2335202390 hasConcept C2780849966 @default.
• W2335202390 hasConcept C509974204 @default.
• W2335202390 hasConcept C71924100 @default.
• W2335202390 hasConceptScore W2335202390C121608353 @default.
• W2335202390 hasConceptScore W2335202390C126322002 @default.
• W2335202390 hasConceptScore W2335202390C126894567 @default.
• W2335202390 hasConceptScore W2335202390C141071460 @default.
• W2335202390 hasConceptScore W2335202390C143998085 @default.
• W2335202390 hasConceptScore W2335202390C2775862295 @default.
• W2335202390 hasConceptScore W2335202390C2777008409 @default.
• W2335202390 hasConceptScore W2335202390C2779466945 @default.
• W2335202390 hasConceptScore W2335202390C2780192828 @default.
• W2335202390 hasConceptScore W2335202390C2780849966 @default.
• W2335202390 hasConceptScore W2335202390C509974204 @default.
• W2335202390 hasConceptScore W2335202390C71924100 @default.
• W2335202390 hasIssue "4S" @default.
• W2335202390 hasLocation W23352023901 @default.
• W2335202390 hasOpenAccess W2335202390 @default.
• W2335202390 hasPrimaryLocation W23352023901 @default.
• W2335202390 hasRelatedWork W2072198445 @default.
• W2335202390 hasRelatedWork W2116884624 @default.
• W2335202390 hasRelatedWork W2170401524 @default.
• W2335202390 hasRelatedWork W2191822645 @default.
• W2335202390 hasRelatedWork W2222314059 @default.
• W2335202390 hasRelatedWork W2305959020 @default.
• W2335202390 hasRelatedWork W2941990228 @default.
• W2335202390 hasRelatedWork W3021750807 @default.
• W2335202390 hasRelatedWork W4313530623 @default.
• W2335202390 hasRelatedWork W71823916 @default.
• W2335202390 hasVolume "187" @default.
• W2335202390 isParatext "false" @default.
• W2335202390 isRetracted "false" @default.
• W2335202390 magId "2335202390" @default.
• W2335202390 workType "article" @default.