Matches in SemOpenAlex for { <https://semopenalex.org/work/W2335211609> ?p ?o ?g. }
- W2335211609 abstract "Abstract Chronic kidney disease (CKD) results in the accumulation of metabolic waste products that are normally cleared by the kidney, known as uremia. Many of these waste products are from bacteria metabolites in the gut. Accumulation of uremic toxins in plasma and tissue, as well as the gut-plasma-tissue metabolic axis are important for understanding pathophysiological mechanisms of comorbidities in CKD. In this study, an untargeted metabolomics approach was used to determine uremic toxin accumulation in plasma, liver, heart and kidney tissue in rats with adenine-induced CKD. Rats with CKD were also given AST-120, a spherical carbon adsorbent, to assess metabolic changes in plasma and tissues with the removal of gut-derived uremic toxins. AST-120 decreased >55% of metabolites that were increased in plasma, liver and heart tissue of rats with CKD. CKD was primarily defined by 8 gut-derived uremic toxins, which were significantly increased in plasma and all tissues. These metabolites were derived from aromatic amino acids and soy protein including: indoxyl sulfate, p-cresyl sulfate, hippuric acid, phenyl sulfate, pyrocatechol sulfate, 4-ethylphenyl sulfate, p-cresol glucuronide and equol 7-glucuronide. Our results highlight the importance of diet and gut-derived metabolites in the accumulation of uremic toxins and define the gut-plasma-tissue metabolic axis in CKD." @default.
- W2335211609 created "2016-06-24" @default.
- W2335211609 creator A5001073923 @default.
- W2335211609 creator A5010124092 @default.
- W2335211609 creator A5050560885 @default.
- W2335211609 creator A5056637200 @default.
- W2335211609 creator A5063607068 @default.
- W2335211609 creator A5065672971 @default.
- W2335211609 creator A5069439615 @default.
- W2335211609 creator A5074829761 @default.
- W2335211609 creator A5078006453 @default.
- W2335211609 creator A5085248037 @default.
- W2335211609 date "2016-03-02" @default.
- W2335211609 modified "2023-10-13" @default.
- W2335211609 title "Untargeted plasma and tissue metabolomics in rats with chronic kidney disease given AST-120" @default.
- W2335211609 cites W107379563 @default.
- W2335211609 cites W110530710 @default.
- W2335211609 cites W113598410 @default.
- W2335211609 cites W1483354304 @default.
- W2335211609 cites W1955298113 @default.
- W2335211609 cites W1968430889 @default.
- W2335211609 cites W1976327004 @default.
- W2335211609 cites W1977559038 @default.
- W2335211609 cites W1984205989 @default.
- W2335211609 cites W1998473661 @default.
- W2335211609 cites W1999232313 @default.
- W2335211609 cites W2000118200 @default.
- W2335211609 cites W2004545653 @default.
- W2335211609 cites W2010427019 @default.
- W2335211609 cites W2015875889 @default.
- W2335211609 cites W2027852347 @default.
- W2335211609 cites W2028573321 @default.
- W2335211609 cites W2028933308 @default.
- W2335211609 cites W2036613336 @default.
- W2335211609 cites W2038233030 @default.
- W2335211609 cites W2038820295 @default.
- W2335211609 cites W2045948096 @default.
- W2335211609 cites W2046965677 @default.
- W2335211609 cites W2050638932 @default.
- W2335211609 cites W2060804509 @default.
- W2335211609 cites W2065342065 @default.
- W2335211609 cites W2069715332 @default.
- W2335211609 cites W2069933411 @default.
- W2335211609 cites W2084023408 @default.
- W2335211609 cites W2087828946 @default.
- W2335211609 cites W2090389897 @default.
- W2335211609 cites W2093740554 @default.
- W2335211609 cites W2094838655 @default.
- W2335211609 cites W2108822380 @default.
- W2335211609 cites W2114997404 @default.
- W2335211609 cites W2115944543 @default.
- W2335211609 cites W2118326977 @default.
- W2335211609 cites W2120827301 @default.
- W2335211609 cites W2122231873 @default.
- W2335211609 cites W2124451420 @default.
- W2335211609 cites W2128606426 @default.
- W2335211609 cites W2130134727 @default.
- W2335211609 cites W2135140841 @default.
- W2335211609 cites W2145073188 @default.
- W2335211609 cites W2148135123 @default.
- W2335211609 cites W2152088948 @default.
- W2335211609 cites W2154375362 @default.
- W2335211609 cites W2157846351 @default.
- W2335211609 cites W2159759437 @default.
- W2335211609 cites W2167540852 @default.
- W2335211609 cites W2167578151 @default.
- W2335211609 cites W2168987491 @default.
- W2335211609 cites W2326995950 @default.
- W2335211609 cites W2336698670 @default.
- W2335211609 cites W2488868277 @default.
- W2335211609 cites W2607031541 @default.
- W2335211609 cites W2917460857 @default.
- W2335211609 cites W4242770839 @default.
- W2335211609 cites W4253946839 @default.
- W2335211609 cites W803284508 @default.
- W2335211609 doi "https://doi.org/10.1038/srep22526" @default.
- W2335211609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4773761" @default.
- W2335211609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26932318" @default.
- W2335211609 hasPublicationYear "2016" @default.
- W2335211609 type Work @default.
- W2335211609 sameAs 2335211609 @default.
- W2335211609 citedByCount "57" @default.
- W2335211609 countsByYear W23352116092016 @default.
- W2335211609 countsByYear W23352116092017 @default.
- W2335211609 countsByYear W23352116092018 @default.
- W2335211609 countsByYear W23352116092019 @default.
- W2335211609 countsByYear W23352116092020 @default.
- W2335211609 countsByYear W23352116092021 @default.
- W2335211609 countsByYear W23352116092022 @default.
- W2335211609 countsByYear W23352116092023 @default.
- W2335211609 crossrefType "journal-article" @default.
- W2335211609 hasAuthorship W2335211609A5001073923 @default.
- W2335211609 hasAuthorship W2335211609A5010124092 @default.
- W2335211609 hasAuthorship W2335211609A5050560885 @default.
- W2335211609 hasAuthorship W2335211609A5056637200 @default.
- W2335211609 hasAuthorship W2335211609A5063607068 @default.
- W2335211609 hasAuthorship W2335211609A5065672971 @default.
- W2335211609 hasAuthorship W2335211609A5069439615 @default.
- W2335211609 hasAuthorship W2335211609A5074829761 @default.
- W2335211609 hasAuthorship W2335211609A5078006453 @default.