Matches in SemOpenAlex for { <https://semopenalex.org/work/W2335266265> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2335266265 endingPage "596" @default.
- W2335266265 startingPage "591" @default.
- W2335266265 abstract "Severe spastic tone and/or spastic hypertonia can be the most disabling consequences of a neurologic insult, resulting from an excess of muscle tone. Baclofen, a GABA-B agonist, is one of the most widely used drugs in treating abnormal or disabling spastic tone. However, the effectiveness of baclofen taken orally is often limited by its systemic side effects, including sedation, confusion, and lethargy. Intrathecal baclofen (ITB) delivered by an implanted catheter can work directly at the spinal cord level to reduce spastic tone through presynaptic inhibition. Several decades after Penn and Kroin (1984) proved that continuous infusion of intrathecal baclofen reduced spinal cord spasticity, numerous studies have demonstrated the benefits of ITB therapy and proven its effectiveness in modulating and reducing spastic tone. In this article the authors review current methods of management with ITB therapy; summarize the current knowledge, controversies, and available scientific literature; illustrate through different clinical cases treatment strategies and their outcomes; and lastly, provide a synopsis of current clinical practice in ITB therapy with insights into new therapeutic developments." @default.
- W2335266265 created "2016-06-24" @default.
- W2335266265 creator A5014665460 @default.
- W2335266265 creator A5045563003 @default.
- W2335266265 creator A5047715924 @default.
- W2335266265 date "2014-12-17" @default.
- W2335266265 modified "2023-09-25" @default.
- W2335266265 title "Spasticity and Intrathecal Baclofen" @default.
- W2335266265 cites W1519306115 @default.
- W2335266265 cites W1540039982 @default.
- W2335266265 cites W1925365775 @default.
- W2335266265 cites W1977491019 @default.
- W2335266265 cites W1991396150 @default.
- W2335266265 cites W1994316794 @default.
- W2335266265 cites W1994799682 @default.
- W2335266265 cites W2010140673 @default.
- W2335266265 cites W2014625496 @default.
- W2335266265 cites W2018540272 @default.
- W2335266265 cites W2026944527 @default.
- W2335266265 cites W2050444794 @default.
- W2335266265 cites W2055966332 @default.
- W2335266265 cites W2056420352 @default.
- W2335266265 cites W2093054096 @default.
- W2335266265 cites W2102924247 @default.
- W2335266265 cites W2110303328 @default.
- W2335266265 cites W2130873978 @default.
- W2335266265 cites W2134622564 @default.
- W2335266265 cites W2134632166 @default.
- W2335266265 cites W2136803351 @default.
- W2335266265 cites W2137916523 @default.
- W2335266265 doi "https://doi.org/10.1055/s-0034-1396012" @default.
- W2335266265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25520030" @default.
- W2335266265 hasPublicationYear "2014" @default.
- W2335266265 type Work @default.
- W2335266265 sameAs 2335266265 @default.
- W2335266265 citedByCount "18" @default.
- W2335266265 countsByYear W23352662652015 @default.
- W2335266265 countsByYear W23352662652016 @default.
- W2335266265 countsByYear W23352662652017 @default.
- W2335266265 countsByYear W23352662652019 @default.
- W2335266265 countsByYear W23352662652020 @default.
- W2335266265 countsByYear W23352662652021 @default.
- W2335266265 countsByYear W23352662652022 @default.
- W2335266265 crossrefType "journal-article" @default.
- W2335266265 hasAuthorship W2335266265A5014665460 @default.
- W2335266265 hasAuthorship W2335266265A5045563003 @default.
- W2335266265 hasAuthorship W2335266265A5047715924 @default.
- W2335266265 hasConcept C126322002 @default.
- W2335266265 hasConcept C170493617 @default.
- W2335266265 hasConcept C2776195251 @default.
- W2335266265 hasConcept C2776814716 @default.
- W2335266265 hasConcept C2778399450 @default.
- W2335266265 hasConcept C2778938600 @default.
- W2335266265 hasConcept C2779012798 @default.
- W2335266265 hasConcept C2779248504 @default.
- W2335266265 hasConcept C2779421357 @default.
- W2335266265 hasConcept C2781201050 @default.
- W2335266265 hasConcept C2781375409 @default.
- W2335266265 hasConcept C42219234 @default.
- W2335266265 hasConcept C71924100 @default.
- W2335266265 hasConcept C99508421 @default.
- W2335266265 hasConceptScore W2335266265C126322002 @default.
- W2335266265 hasConceptScore W2335266265C170493617 @default.
- W2335266265 hasConceptScore W2335266265C2776195251 @default.
- W2335266265 hasConceptScore W2335266265C2776814716 @default.
- W2335266265 hasConceptScore W2335266265C2778399450 @default.
- W2335266265 hasConceptScore W2335266265C2778938600 @default.
- W2335266265 hasConceptScore W2335266265C2779012798 @default.
- W2335266265 hasConceptScore W2335266265C2779248504 @default.
- W2335266265 hasConceptScore W2335266265C2779421357 @default.
- W2335266265 hasConceptScore W2335266265C2781201050 @default.
- W2335266265 hasConceptScore W2335266265C2781375409 @default.
- W2335266265 hasConceptScore W2335266265C42219234 @default.
- W2335266265 hasConceptScore W2335266265C71924100 @default.
- W2335266265 hasConceptScore W2335266265C99508421 @default.
- W2335266265 hasIssue "05" @default.
- W2335266265 hasLocation W23352662651 @default.
- W2335266265 hasLocation W23352662652 @default.
- W2335266265 hasOpenAccess W2335266265 @default.
- W2335266265 hasPrimaryLocation W23352662651 @default.
- W2335266265 hasRelatedWork W1508424669 @default.
- W2335266265 hasRelatedWork W1984597580 @default.
- W2335266265 hasRelatedWork W2083048482 @default.
- W2335266265 hasRelatedWork W2084833588 @default.
- W2335266265 hasRelatedWork W2105240531 @default.
- W2335266265 hasRelatedWork W2283016216 @default.
- W2335266265 hasRelatedWork W2335266265 @default.
- W2335266265 hasRelatedWork W2412280286 @default.
- W2335266265 hasRelatedWork W3025316848 @default.
- W2335266265 hasRelatedWork W3166422240 @default.
- W2335266265 hasVolume "34" @default.
- W2335266265 isParatext "false" @default.
- W2335266265 isRetracted "false" @default.
- W2335266265 magId "2335266265" @default.
- W2335266265 workType "article" @default.