Matches in SemOpenAlex for { <https://semopenalex.org/work/W2335281311> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2335281311 endingPage "A26" @default.
- W2335281311 startingPage "A26" @default.
- W2335281311 abstract "<h3></h3> Psychiatric changes, dementia and motor dysfunction are hallmarks of Huntington disease (HD), a neurodegenerative disorder genetically characterised by the presence of expanded CAG repeats in the HTT gene.The behavioural characterisation of a valid rodent model for HD is critical, especially in light of the development of therapeutic strategies for HD. BACHD transgenic rats, carrying the human full length mutated HTT (97 CAG-CAA repeats) display a robust, early onset and progressive HD-like phenotype including motor deficits and anxiety-related symptoms. We evaluated the impulsive action (IA), defined as the inability to withhold a prepotent motor response.IA of 5 months old BACHD rats was assessed using the DRL (Differential Reinforcement of Low rates of responding task). Rats were trained progressively through a series of two reinforcement schedules (DRL-5 and -10 s) that required them to withhold responding for the appropriate amount of time before a lever press was reinforced. Relative to controls, BACHD rats displayed a decrease in response efficiency during DRL-10. This lack was not present during the DRL-5 schedule, showing that BACHD rats can withhold an instrumental response only for short periods of time. We also observed that BACHD rats displayed deficits in behavioural inhibition (i.e. increased responding during non-reinforced periods) that were mainly evident during the ‘burst’ (0–2s inter response time, IRT) in the DRL-10 schedule.Taken together, these data suggest that deficits in the ability to inhibit lever press responding at increasing IRTs predict greater impulsive action of this transgenic rat model of Huntington’s disease." @default.
- W2335281311 created "2016-06-24" @default.
- W2335281311 creator A5025779892 @default.
- W2335281311 creator A5035822776 @default.
- W2335281311 creator A5068019342 @default.
- W2335281311 creator A5079400265 @default.
- W2335281311 date "2014-09-01" @default.
- W2335281311 modified "2023-09-26" @default.
- W2335281311 title "C05 Differential-reinforcement-of-low-rates-of-responding-task Performance In A Transgenic Rat Model Of Huntington Disease" @default.
- W2335281311 doi "https://doi.org/10.1136/jnnp-2014-309032.78" @default.
- W2335281311 hasPublicationYear "2014" @default.
- W2335281311 type Work @default.
- W2335281311 sameAs 2335281311 @default.
- W2335281311 citedByCount "0" @default.
- W2335281311 crossrefType "journal-article" @default.
- W2335281311 hasAuthorship W2335281311A5025779892 @default.
- W2335281311 hasAuthorship W2335281311A5035822776 @default.
- W2335281311 hasAuthorship W2335281311A5068019342 @default.
- W2335281311 hasAuthorship W2335281311A5079400265 @default.
- W2335281311 hasConcept C102230213 @default.
- W2335281311 hasConcept C104317684 @default.
- W2335281311 hasConcept C126322002 @default.
- W2335281311 hasConcept C138496976 @default.
- W2335281311 hasConcept C15744967 @default.
- W2335281311 hasConcept C169760540 @default.
- W2335281311 hasConcept C2779134260 @default.
- W2335281311 hasConcept C2780647506 @default.
- W2335281311 hasConcept C3018324008 @default.
- W2335281311 hasConcept C54355233 @default.
- W2335281311 hasConcept C548259974 @default.
- W2335281311 hasConcept C67203356 @default.
- W2335281311 hasConcept C71924100 @default.
- W2335281311 hasConcept C77805123 @default.
- W2335281311 hasConcept C86803240 @default.
- W2335281311 hasConceptScore W2335281311C102230213 @default.
- W2335281311 hasConceptScore W2335281311C104317684 @default.
- W2335281311 hasConceptScore W2335281311C126322002 @default.
- W2335281311 hasConceptScore W2335281311C138496976 @default.
- W2335281311 hasConceptScore W2335281311C15744967 @default.
- W2335281311 hasConceptScore W2335281311C169760540 @default.
- W2335281311 hasConceptScore W2335281311C2779134260 @default.
- W2335281311 hasConceptScore W2335281311C2780647506 @default.
- W2335281311 hasConceptScore W2335281311C3018324008 @default.
- W2335281311 hasConceptScore W2335281311C54355233 @default.
- W2335281311 hasConceptScore W2335281311C548259974 @default.
- W2335281311 hasConceptScore W2335281311C67203356 @default.
- W2335281311 hasConceptScore W2335281311C71924100 @default.
- W2335281311 hasConceptScore W2335281311C77805123 @default.
- W2335281311 hasConceptScore W2335281311C86803240 @default.
- W2335281311 hasIssue "Suppl 1" @default.
- W2335281311 hasLocation W23352813111 @default.
- W2335281311 hasOpenAccess W2335281311 @default.
- W2335281311 hasPrimaryLocation W23352813111 @default.
- W2335281311 hasRelatedWork W1990543810 @default.
- W2335281311 hasRelatedWork W1998095657 @default.
- W2335281311 hasRelatedWork W2057414348 @default.
- W2335281311 hasRelatedWork W2058838770 @default.
- W2335281311 hasRelatedWork W2062574812 @default.
- W2335281311 hasRelatedWork W2077383779 @default.
- W2335281311 hasRelatedWork W2724194295 @default.
- W2335281311 hasRelatedWork W2733006186 @default.
- W2335281311 hasRelatedWork W2011915936 @default.
- W2335281311 hasRelatedWork W2887751608 @default.
- W2335281311 hasVolume "85" @default.
- W2335281311 isParatext "false" @default.
- W2335281311 isRetracted "false" @default.
- W2335281311 magId "2335281311" @default.
- W2335281311 workType "article" @default.