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- W2335304568 abstract "Epidemiologic and molecular evidence obtained over the past decade has linked genital human papillomavirus (HPV) infection etiologically to the development of cervical cancer, which is the second most common cancer of women worldwide. The genital HPV types that are associated with cervical cancer are designated high-risk, while the others are designated low-risk. However, even infection with a high-risk HPV type is usually inapparent and self-limited. Thus, although HPV infection precedes the development of cervical tumors, other factors, such as sustained high level virus expression, immune status, and genetic background, seem to determine progression to malignancy. The pathogenesis of HPV-associated anal cancers appears to be similar. The association of high-risk HPV types with cervical cancer is correlated with the ability of these HPV types to immortalize cultured human keratinocytes; under similar growth conditions, low-risk types lack this property. Immortalization is linked to two viral genes E6 and E7,, which are also the two viral genes that are preferentially retained and expressed in cervical cancers and in tumor derived cell lines. The E6 protein from high-risk HPV types binds and degrades wild type p53 much more efficiently than E6 from low-risk virus, while high-risk E7 binds and inactivates pRb better than low-risk E7. Identification of genital HPV infection as a important step in the pathogenesis of cervical cancer has focused attention on developing a vaccine against the virus. To this end, lower eukaryotic cells can produce preparative amounts of properly-folded self-assembled virus-like particles (VLP) composed of the major structural viral protein L1. Such VLPs can induce neutralizing antibodies in animals and protect animals against subsequent experimental papillomavirus infection. As protection in animals depends upon the presence of antibodies directed against type-specific conformational L1 epitopes, it is likely that protection in humans will also be type-specific. Therefore it will probably be necessary to have a multivalent vaccine composed of particles from the various HPV types found most frequently in human cancers." @default.
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- W2335304568 date "1997-04-01" @default.
- W2335304568 modified "2023-10-16" @default.
- W2335304568 title "HPV AND CERVICAL CANCER" @default.
- W2335304568 doi "https://doi.org/10.1097/00042560-199704010-00025" @default.
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