Matches in SemOpenAlex for { <https://semopenalex.org/work/W2335322591> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W2335322591 abstract "Retinoblastoma is a rare eye cancer form in both benign and malignant tumour especially affecting child. Retinoblastoma-1 is a tumour suppressor gene. Functionality of the protein specified in two pockets A (amino acid 394 to 572) and pocket B (amino acid 646 to 792). This binding site is mainly involved in normal function of Retinoblastoma-1 tumour suppressor activity. In the present study we have analyzed antitumour activity for human eye cancer from cyclophosphamide analogs. Totally we selected ten cyclophosphamide analogs and one currently available market drug cyclophosphamide as a reference compounds for molecular docking studies against human eye cancer protein Retinoblastoma-1 and also Absorption Distribution Metabolism Excretion properties of these compounds were carried out by using Qikprop. Among the many cyclophosphamide analogs one of them (Perfosfamide) are showing best glide score and more num- ber of hydrogen bond against human eye cancer protein Retinoblastoma. and it was found to be under acceptable range with predicted ADME properties. From the molecular interaction studies we are concluding that the above mentioned cyclophosphamide analogs Per- fosfamide have best anti tumour activity against human eye cancer." @default.
- W2335322591 created "2016-06-24" @default.
- W2335322591 creator A5076732548 @default.
- W2335322591 date "2012-01-01" @default.
- W2335322591 modified "2023-09-27" @default.
- W2335322591 title "Molecular Interaction Studies of 3D Conformers of Cyclophosphamide against Human Eye Cancer Protein Retinoblastoma 1" @default.
- W2335322591 cites W2131488073 @default.
- W2335322591 doi "https://doi.org/10.4172/scientificreports.471" @default.
- W2335322591 hasPublicationYear "2012" @default.
- W2335322591 type Work @default.
- W2335322591 sameAs 2335322591 @default.
- W2335322591 citedByCount "0" @default.
- W2335322591 crossrefType "journal-article" @default.
- W2335322591 hasAuthorship W2335322591A5076732548 @default.
- W2335322591 hasConcept C104317684 @default.
- W2335322591 hasConcept C126322002 @default.
- W2335322591 hasConcept C178790620 @default.
- W2335322591 hasConcept C185592680 @default.
- W2335322591 hasConcept C18705241 @default.
- W2335322591 hasConcept C2776577112 @default.
- W2335322591 hasConcept C2776694085 @default.
- W2335322591 hasConcept C2776755627 @default.
- W2335322591 hasConcept C32909587 @default.
- W2335322591 hasConcept C502942594 @default.
- W2335322591 hasConcept C55493867 @default.
- W2335322591 hasConcept C71924100 @default.
- W2335322591 hasConceptScore W2335322591C104317684 @default.
- W2335322591 hasConceptScore W2335322591C126322002 @default.
- W2335322591 hasConceptScore W2335322591C178790620 @default.
- W2335322591 hasConceptScore W2335322591C185592680 @default.
- W2335322591 hasConceptScore W2335322591C18705241 @default.
- W2335322591 hasConceptScore W2335322591C2776577112 @default.
- W2335322591 hasConceptScore W2335322591C2776694085 @default.
- W2335322591 hasConceptScore W2335322591C2776755627 @default.
- W2335322591 hasConceptScore W2335322591C32909587 @default.
- W2335322591 hasConceptScore W2335322591C502942594 @default.
- W2335322591 hasConceptScore W2335322591C55493867 @default.
- W2335322591 hasConceptScore W2335322591C71924100 @default.
- W2335322591 hasIssue "10" @default.
- W2335322591 hasLocation W23353225911 @default.
- W2335322591 hasOpenAccess W2335322591 @default.
- W2335322591 hasPrimaryLocation W23353225911 @default.
- W2335322591 hasRelatedWork W2036802760 @default.
- W2335322591 hasRelatedWork W2091048247 @default.
- W2335322591 hasRelatedWork W2095540358 @default.
- W2335322591 hasRelatedWork W2128160797 @default.
- W2335322591 hasRelatedWork W2408796426 @default.
- W2335322591 hasRelatedWork W2570968120 @default.
- W2335322591 hasRelatedWork W2748952813 @default.
- W2335322591 hasRelatedWork W2899084033 @default.
- W2335322591 hasRelatedWork W4226017683 @default.
- W2335322591 hasRelatedWork W4249342726 @default.
- W2335322591 hasVolume "01" @default.
- W2335322591 isParatext "false" @default.
- W2335322591 isRetracted "false" @default.
- W2335322591 magId "2335322591" @default.
- W2335322591 workType "article" @default.