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- W2335345353 abstract "Sirtuins (SIRT1-7) and telomerase (TERT) are known to be involved in the regulation of cellular senescence/ aging processes. Resveratrol (Rsv), a natural polyphenol, which has been shown to extend the lifespan of diverse range of species. Furthermore, Rsv has been shown to activate SIRT1, the class III NAD+ dependent histone deacetylases (HDACs), directly in mammalian cells. Here, we examined the changes in promoter activities of the human SIRT1 and TERT genes after treatment with Rsv and lignin glycosidases/lignin carbohydrate complexes (LCC) extracted from pine cones of Pinus Karalensis. We constructed Luciferase (Luc) expression vectors, pGL4- SIRT1 and pGL4-TERT, containing 396-bp and 263-bp of the 5’-upstream regions of human SIRT1 and TERT genes, respectively, which were then transfected into HeLa S3 cells. The Luc reporter plasmid assay revealed that treatment with the LCC increases not only SIRT1 but also TERT promoter activities more than that with Rsv. These results suggest that the LCC from pine cones induces expression of both SIRT1 and TERT genes, which is thought to have anti-aging effects." @default.
- W2335345353 created "2016-06-24" @default.
- W2335345353 creator A5015299418 @default.
- W2335345353 date "2013-01-01" @default.
- W2335345353 modified "2023-09-28" @default.
- W2335345353 title "Effect of Lignin Glycosides Extracted from Pine Cones on the Human SIRT1 Promoter" @default.
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- W2335345353 doi "https://doi.org/10.4172/2153-2435.1000266" @default.
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