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- W2335350977 abstract "Pancreatic Ductal Adenocarcinoma (PDAC) is the fourth most common cause of cancer in men and fifth in women in the United States. The overall survival rate is very poor in PDAC due to late presentation, tumor aggressiveness and lack of effective treatment strategy. The objective of this study is to explore the role of Cyr61 in the progression of the PDAC. Cyr61/CCN1 is a secreted, cysteine-rich heparin-binding protein, a member of CCN family and also plays a role in cell proliferation, adhesion, migration and differentiation during development but very little is known about cancer biology. We studied Cyr61 mRNA expression and protein level in tissue samples (archival and tissue array samples) using In Situ hybridization and immunohistochemistry. Its expression was also studied in different cell lines using Northern Blotting, quantitative real time PCR and Western blot analysis. The studies revealed that Cyr61 mRNA and protein was highly expressed in PDAC as compared to normal and chronic pancreatitis sections. The expression profile of Cyr61 increases as the disease progressed from Grade I to Grade III. Interestingly, in some PDAC sections Cyr61 expression was undetected or barely detected. Cyr61 was highly expressed in Panc-1, an invasive cell line, as compared to less invasive cell lines (i.e., BxPC3 and Capan-1) where expression of Cyr61 is very minimal. In order to evaluate the functional role of Cyr61, we nullified Cyr61 in Panc-1 cells using retroviral-mediated shRNA. We determined the migration of these cells and the effect of the conditioned media of these cells on in vitro angiogenesis. We found that Cyr61 is essential for in vitro migration and induction of angiogenesis. Furthermore, these studies reveal that Cyr61 contributes in the development of drug resistance. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2962." @default.
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- W2335350977 date "2010-04-15" @default.
- W2335350977 modified "2023-09-24" @default.
- W2335350977 title "Abstract 2962: Role of Cyr61 in the progression of pancreatic cancer" @default.
- W2335350977 doi "https://doi.org/10.1158/1538-7445.am10-2962" @default.
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