Matches in SemOpenAlex for { <https://semopenalex.org/work/W2335366986> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2335366986 endingPage "116" @default.
- W2335366986 startingPage "107" @default.
- W2335366986 abstract "MicroRNAs (miRNAs) are endogenous ∼22-nucleotide non-coding RNAs that regulate gene expression through the translational repression or degradation of target mRNAs. The human genome contains over 1400 miRNAs and over 60% of human mRNAs are predicted to be targets of miRNAs. The miRNAs have roles in fine-tuning the expression of their target genes forming intricate networks. Research on miRNA is growing exponentially, and it is now clear that miRNAs can potentially regulate every aspect of cellular processes such as differentiation, proliferation and apoptosis as well as a large range of physiological processes such as development, immune response, metabolism, tumor formation, and disease development. The roles of miRNAs in the metabolism of xenobiotics and endobiotics have only recently been revealed. This review describes the current knowledge on the regulation of cytochrome P450s and transcriptional factors by miRNAs, and its physiological and clinical significance, which were disclosed in our studies. The miRNA expression is readily altered by chemicals, carcinogens, drugs, hormones, stress, or diseases, and the dysregulation of specific miRNAs might lead to changes in the drug metabolism potency or pharmacokinetics as well as pathophysiological changes. Utilizing miRNAs opens a new era in the fields of drug metabolism and pharmacokinetics as well as toxicology." @default.
- W2335366986 created "2016-06-24" @default.
- W2335366986 creator A5001851785 @default.
- W2335366986 date "2012-01-01" @default.
- W2335366986 modified "2023-10-18" @default.
- W2335366986 title "Role of MicroRNAs in the Regulation of Cytochrome P450s and Transcriptional Factors" @default.
- W2335366986 cites W1584027470 @default.
- W2335366986 cites W1976760756 @default.
- W2335366986 cites W1984782013 @default.
- W2335366986 cites W1985825541 @default.
- W2335366986 cites W1992461587 @default.
- W2335366986 cites W1994958726 @default.
- W2335366986 cites W2007103799 @default.
- W2335366986 cites W2010955626 @default.
- W2335366986 cites W2034889832 @default.
- W2335366986 cites W2052325097 @default.
- W2335366986 cites W2063210085 @default.
- W2335366986 cites W2114465406 @default.
- W2335366986 cites W2135374261 @default.
- W2335366986 cites W2150536104 @default.
- W2335366986 cites W2163048959 @default.
- W2335366986 doi "https://doi.org/10.1248/yakushi.132.107" @default.
- W2335366986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22214585" @default.
- W2335366986 hasPublicationYear "2012" @default.
- W2335366986 type Work @default.
- W2335366986 sameAs 2335366986 @default.
- W2335366986 citedByCount "1" @default.
- W2335366986 countsByYear W23353669862015 @default.
- W2335366986 crossrefType "journal-article" @default.
- W2335366986 hasAuthorship W2335366986A5001851785 @default.
- W2335366986 hasBestOaLocation W23353669861 @default.
- W2335366986 hasConcept C104317684 @default.
- W2335366986 hasConcept C145059251 @default.
- W2335366986 hasConcept C150194340 @default.
- W2335366986 hasConcept C165864922 @default.
- W2335366986 hasConcept C54355233 @default.
- W2335366986 hasConcept C70721500 @default.
- W2335366986 hasConcept C86803240 @default.
- W2335366986 hasConcept C95444343 @default.
- W2335366986 hasConceptScore W2335366986C104317684 @default.
- W2335366986 hasConceptScore W2335366986C145059251 @default.
- W2335366986 hasConceptScore W2335366986C150194340 @default.
- W2335366986 hasConceptScore W2335366986C165864922 @default.
- W2335366986 hasConceptScore W2335366986C54355233 @default.
- W2335366986 hasConceptScore W2335366986C70721500 @default.
- W2335366986 hasConceptScore W2335366986C86803240 @default.
- W2335366986 hasConceptScore W2335366986C95444343 @default.
- W2335366986 hasIssue "1" @default.
- W2335366986 hasLocation W23353669861 @default.
- W2335366986 hasLocation W23353669862 @default.
- W2335366986 hasOpenAccess W2335366986 @default.
- W2335366986 hasPrimaryLocation W23353669861 @default.
- W2335366986 hasRelatedWork W1551232230 @default.
- W2335366986 hasRelatedWork W166274801 @default.
- W2335366986 hasRelatedWork W1817708259 @default.
- W2335366986 hasRelatedWork W1971980958 @default.
- W2335366986 hasRelatedWork W1988455047 @default.
- W2335366986 hasRelatedWork W2026528132 @default.
- W2335366986 hasRelatedWork W2026631764 @default.
- W2335366986 hasRelatedWork W2077423437 @default.
- W2335366986 hasRelatedWork W2099551708 @default.
- W2335366986 hasRelatedWork W2119996501 @default.
- W2335366986 hasVolume "132" @default.
- W2335366986 isParatext "false" @default.
- W2335366986 isRetracted "false" @default.
- W2335366986 magId "2335366986" @default.
- W2335366986 workType "article" @default.