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- W2335484199 abstract "Monitoring the area under the concentration-time curve (AUC) of drugs has been advocated for therapeutic drug monitoring (TDM) as a means of making adjustments to achieve the optimal dose. However, conventional methods of measuring AUC require many blood samples to be taken after administering the drug, which is not viable in clinical practice. In this study, AUC monitoring was adapted to TDM for HIV protease inhibitors (PI) in HIV-infected patients, by designing equations for estimating the AUC using a small number of blood samples. In multiple regression analysis using cumulative PI plasma data from HIV-infected patients, it was found that trough levels (C0) could not explain the variation in their AUC values. In patients treated with ritonavir (RTV) plus indinavir (IDV), the optimum and minimum sampling time points for estimating the AUC of IDV were C0and C2 (R2=0.904). In patients treated with RTV plus saquinavir (SQV), the optimum and minimum sampling time points for both drugs were C0and C4 (R2=0.957, 0.967, respectively). In patients treated with Kaletra (combination of RTV and lopinavir (LPV)), the contribution of plasma LPV to the AUC of LPV at any sampling time was very small. However, the plasma concentration of RTV correlated well with the AUC of LPV, and the optimum and minimum sampling time points for estimating the AUC of LPV were C0and C6for LPV and C6for RTV (R2=0.904). These results suggest that our equations could be used successfully for estimating the AUC of PIs in clinical practice from a small number of samples." @default.
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- W2335484199 date "2004-01-01" @default.
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- W2335484199 title "Equations for Estimating Area under Concentration Versus Time Curves for HIV Protease Inhibitors Used in HIV-Infected Patients and Evaluation of Their Effectiveness" @default.
- W2335484199 doi "https://doi.org/10.5649/jjphcs.30.429" @default.
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