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• W2335528247 abstract "To evaluate the cost-effectiveness of the Three I's for HIV/TB (human immunodeficiency virus/tuberculosis): antiretroviral therapy (ART), intensified TB case finding (ICF), isoniazid preventive treatment (IPT), and TB infection control (IC).Using a 3-year decision-analytic model, we estimated the cost-effectiveness of a base scenario (55% ART coverage at CD4 count ⩿350 cells/mm(3)) and 19 strategies that included one or more of the following: 1) 90% ART coverage, 2) IC and 3) ICF using four-symptom screening and 6- or 36-month IPT. The TB diagnostic algorithm included 1) sputum smear microscopy with chest X-ray, and 2) Xpert® MTB/RIF.In resource-constrained settings with a high burden of HIV and TB, the most cost-effective strategies under both diagnostic algorithms included 1) 55% ART coverage and IC, 2) 55% ART coverage, IC and 36-month IPT, and 3) expanded ART at 90% coverage with IC and 36-month IPT. The latter averted more TB cases than other scenarios with increased ART coverage, IC, 6-month IPT and/or IPT for tuberculin skin test positive individuals. The cost-effectiveness results did not change significantly under the sensitivity analyses.Expanded ART to 90% coverage, IC and a 36-month IPT strategy averted most TB cases and is among the cost-effective strategies." @default.
• W2335528247 created "2016-06-24" @default.
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• W2335528247 date "2014-10-01" @default.
• W2335528247 modified "2023-09-24" @default.
• W2335528247 title "Cost-effectiveness of the <I>Three I's for HIV/TB</I> and ART to prevent TB among people living with HIV" @default.
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• W2335528247 doi "https://doi.org/10.5588/ijtld.13.0571" @default.
• W2335528247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4886505" @default.
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