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- W2335552521 abstract "Ruminants are an important reservoir of Escherichia coli O157:H7. To reduce E coli O157:H7 excretion by these animals could play a key role in prevention and control of human infections. In the present study, the authors used 12 three‐month‐old goats to evaluate the efficacy of intranasal administration of the Stx2B‐Tir‐Stx1B‐Zot protein. These goats were inoculated on days 0 and 21 and infected with 10 10 colony‐forming units (cfu) of E coli O157:H7 by oral inoculation on day 36. Faecal shedding was monitored daily for two weeks. All of six goats immunised with recombinant protein elicited significant Stx2b‐Tir‐Stx1b‐Zot‐specific serum IgG antibodies, and three of them also showed production of antigen‐specific IgA in faeces. The immunised goats showed much less shedding of E coli O157:H7 after challenge. These results demonstrate the potential for the use of Stx2B‐Tir‐Stx1B‐Zot protein in mucosal vaccine formulations to prevent colonisation and shedding of E coli O157:H7 in goats." @default.
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- W2335552521 date "2012-02-01" @default.
- W2335552521 modified "2023-09-26" @default.
- W2335552521 title "Intranasal immunisation with Stx2B-Tir-Stx1B-Zot protein leads to decreased shedding in goats after challenge with Escherichia coli O157:H7" @default.
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- W2335552521 doi "https://doi.org/10.1136/vr.100325" @default.
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