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• W2335552961 abstract "Patients with renal impairment have decreased excretion of uric acid, thus being particularly prone to having elevated serum uric acid concentrations. No data are available on the long-term prognostic role of uric acid in patients with ST-elevation myocardial infarction (STEMI) and renal dysfunction, submitted to percutaneous coronary intervention (PCI). We therefore prospectively assessed, in 329 patients with STEMI and renal dysfunction (admission estimated glomerular filtration rate <60 ml/min/1.73 m2), all submitted to PCI, whether uric acid levels are associated with increased mortality at 1-year postdischarge follow-up. Patients in the third tertile of uric acid showed a higher BMI (P = 0.014), a higher incidence of hypertension (P = 0.029), and two or more comorbidities (P = 0.034). The highest incidence of bleeding and of acute kidney injury was detectable in patients in the third tertile (P = 0.011 and P < 0.001, respectively) who showed the highest mortality rate at 1-year postdischarge follow-up (P = 0.008). At Cox regression analysis, uric acid was an independent predictor of 1-year postdischarge mortality (hazard ratio 1.26, 95% confidence interval 1.06–1.51, P = 0.011). In STEMI patients with estimated glomerular filtration rate below 60 ml/min/1.73 m2 treated with PCI, uric acid helps in identifying a subset of patients at a higher risk of bleeding and acute kidney injury. Increased uric acid is an independent prognostic risk factor for 1-year mortality. Further studies performed in larger cohorts of patients are needed to confirm our findings and to evaluate whether lowering uric acid in these patients is beneficial." @default.
• W2335552961 created "2016-06-24" @default.
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• W2335552961 date "2015-11-01" @default.
• W2335552961 modified "2023-10-18" @default.
• W2335552961 title "Long-term prognostic role of uric acid in patients with ST-elevation myocardial infarction and renal dysfunction" @default.
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• W2335552961 doi "https://doi.org/10.2459/jcm.0000000000000238" @default.
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