FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2335585513> ?p ?o ?g. }

• W2335585513 abstract "Purpose: We previously showed that rs6007897 (C→T, Ala2268Thr) of the cadherin, EGF LAG seven-pass G-type receptor 1 gene (CELSR1) was significantly associated with ischemic stroke in Japanese individuals by a Genome-Wide Association Study (GWAS). We also identified rs9846911 (A→G) at chromosome 3q28 as a susceptibility locus for chronic kidney disease in Japanese individuals by a GWAS. Given that hypertension is a major risk factor for both ischemic stroke and chronic kidney disease, we hypothesized that the association of rs6007897 of CELSR1 with ischemic stroke or of rs9846911 at 3q28 with chronic kidney disease might be attributable, at least in part, to their effects on genetic susceptibility to hypertension. The purpose of the present study was to examine a possible association of rs6007897 of CELSR1 or rs9846911 at 3q28 with hypertension in community-dwelling Japanese individuals.Methods: Study subjects comprised 5959 community-dwelling individuals (1670 subjects with hypertension, 4289 controls) who were recruited to a population-based cohort study in Inabe City, Japan between 2003 and 2012. The Inabe Study is a longitudinal genetic epidemiological study of atherosclerotic, cardiovascular, and metabolic diseases. The subjects are recruited from individuals who visited the health care center of Inabe General Hospital for an annual health checkup. The subjects with hypertension either had a systolic Blood Pressure (BP) of ≥140 mmHg or diastolic BP of ≥90 mmHg (or both) or had taken antihypertensive medication. The control individuals had systolic BP of <140 mmHg and diastolic BP of <90 mmHg and no history of hypertension or of taking antihypertensive medication.Results: Comparisons of allele frequencies by the chi-square test revealed that rs6007897 of CELSR1 (P = 0.0280) and rs9846911 at 3q28 (P = 0.0171) were significantly associated with hypertension. Multivariable logistic regression analysis with adjustment for age, sex, body mass index, smoking status, the serum concentration of creatinine, and the prevalence of diabetes mellitus and dyslipidemia revealed that rs6007897 (P = 0.0308; recessive model; odds ratio, 1.56) and rs9846911 (P = 0.0353; dominant model; odds ratio, 1.22) were significantly associated with hypertension with the T allele of rs6007897 and the G allele rs984691 representing risk factors for hypertension.Conclusions: CELSR1 and 3q28 may be susceptible loci for hypertension in Japanese individuals. Determination of genotypes for these polymorphisms may prove informative for assessment of the genetic risk for hypertension in the Japanese population." @default.
• W2335585513 created "2016-06-24" @default.
• W2335585513 creator A5002733896 @default.
• W2335585513 creator A5005757028 @default.
• W2335585513 creator A5028242375 @default.
• W2335585513 creator A5034179596 @default.
• W2335585513 creator A5038176848 @default.
• W2335585513 creator A5046424720 @default.
• W2335585513 creator A5047494990 @default.
• W2335585513 creator A5047528236 @default.
• W2335585513 creator A5067757350 @default.
• W2335585513 creator A5069201202 @default.
• W2335585513 date "2013-08-02" @default.
• W2335585513 modified "2023-09-27" @default.
• W2335585513 title "Association of polymorphisms of CELSR1 and chromosome 3q28 with hypertension in community-dwelling Japanese individuals" @default.
• W2335585513 doi "https://doi.org/10.1093/eurheartj/eht308.p1424" @default.
• W2335585513 hasPublicationYear "2013" @default.
• W2335585513 type Work @default.
• W2335585513 sameAs 2335585513 @default.
• W2335585513 citedByCount "0" @default.
• W2335585513 crossrefType "journal-article" @default.
• W2335585513 hasAuthorship W2335585513A5002733896 @default.
• W2335585513 hasAuthorship W2335585513A5005757028 @default.
• W2335585513 hasAuthorship W2335585513A5028242375 @default.
• W2335585513 hasAuthorship W2335585513A5034179596 @default.
• W2335585513 hasAuthorship W2335585513A5038176848 @default.
• W2335585513 hasAuthorship W2335585513A5046424720 @default.
• W2335585513 hasAuthorship W2335585513A5047494990 @default.
• W2335585513 hasAuthorship W2335585513A5047528236 @default.
• W2335585513 hasAuthorship W2335585513A5067757350 @default.
• W2335585513 hasAuthorship W2335585513A5069201202 @default.
• W2335585513 hasBestOaLocation W23355855131 @default.
• W2335585513 hasConcept C104317684 @default.
• W2335585513 hasConcept C106208931 @default.
• W2335585513 hasConcept C107130276 @default.
• W2335585513 hasConcept C126322002 @default.
• W2335585513 hasConcept C127413603 @default.
• W2335585513 hasConcept C135763542 @default.
• W2335585513 hasConcept C153209595 @default.
• W2335585513 hasConcept C2778653478 @default.
• W2335585513 hasConcept C2780645631 @default.
• W2335585513 hasConcept C2908647359 @default.
• W2335585513 hasConcept C54355233 @default.
• W2335585513 hasConcept C71924100 @default.
• W2335585513 hasConcept C78519656 @default.
• W2335585513 hasConcept C84393581 @default.
• W2335585513 hasConcept C86803240 @default.
• W2335585513 hasConcept C99454951 @default.
• W2335585513 hasConceptScore W2335585513C104317684 @default.
• W2335585513 hasConceptScore W2335585513C106208931 @default.
• W2335585513 hasConceptScore W2335585513C107130276 @default.
• W2335585513 hasConceptScore W2335585513C126322002 @default.
• W2335585513 hasConceptScore W2335585513C127413603 @default.
• W2335585513 hasConceptScore W2335585513C135763542 @default.
• W2335585513 hasConceptScore W2335585513C153209595 @default.
• W2335585513 hasConceptScore W2335585513C2778653478 @default.
• W2335585513 hasConceptScore W2335585513C2780645631 @default.
• W2335585513 hasConceptScore W2335585513C2908647359 @default.
• W2335585513 hasConceptScore W2335585513C54355233 @default.
• W2335585513 hasConceptScore W2335585513C71924100 @default.
• W2335585513 hasConceptScore W2335585513C78519656 @default.
• W2335585513 hasConceptScore W2335585513C84393581 @default.
• W2335585513 hasConceptScore W2335585513C86803240 @default.
• W2335585513 hasConceptScore W2335585513C99454951 @default.
• W2335585513 hasLocation W23355855131 @default.
• W2335585513 hasOpenAccess W2335585513 @default.
• W2335585513 hasPrimaryLocation W23355855131 @default.
• W2335585513 hasRelatedWork W1567302232 @default.
• W2335585513 hasRelatedWork W1977222562 @default.
• W2335585513 hasRelatedWork W1988682083 @default.
• W2335585513 hasRelatedWork W2000492522 @default.
• W2335585513 hasRelatedWork W2011141288 @default.
• W2335585513 hasRelatedWork W2015143929 @default.
• W2335585513 hasRelatedWork W2037025027 @default.
• W2335585513 hasRelatedWork W2046160371 @default.
• W2335585513 hasRelatedWork W2069801427 @default.
• W2335585513 hasRelatedWork W2090990310 @default.
• W2335585513 hasRelatedWork W2123535148 @default.
• W2335585513 hasRelatedWork W2174863375 @default.
• W2335585513 hasRelatedWork W2255032448 @default.
• W2335585513 hasRelatedWork W2284695721 @default.
• W2335585513 hasRelatedWork W2397091419 @default.
• W2335585513 hasRelatedWork W2891250112 @default.
• W2335585513 hasRelatedWork W2922120009 @default.
• W2335585513 hasRelatedWork W2995003370 @default.
• W2335585513 hasRelatedWork W3004951611 @default.
• W2335585513 hasRelatedWork W3124100777 @default.
• W2335585513 isParatext "false" @default.
• W2335585513 isRetracted "false" @default.
• W2335585513 magId "2335585513" @default.
• W2335585513 workType "article" @default.