Matches in SemOpenAlex for { <https://semopenalex.org/work/W2335586463> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2335586463 endingPage "A68" @default.
- W2335586463 startingPage "A68" @default.
- W2335586463 abstract "<h3>Purpose</h3> Action potential (AP) contours vary considerably between normal adult and aged left atrial fibres. The ionic and molecular bases for these differences remain unknown. So we investigate whether the L-type calcium current (I<sub>Ca.L</sub>) an L-type calcium channel of left atria may be altered with age. <h3>Method</h3> We used whole-cell patch-clamp to record action potential (AP) and I<sub>Ca.L</sub> in left atrial (LA) cells dispersed from normal adult (2 to 2.5 years) and older canines (>8 years). The a1c (Cav1.2) subunit of L-type calcium channel mRNA and protein expression were assessed by real-time quantitative RT-PCR and Western blotting respectively. <h3>Results</h3> Whereas the potential remains, AP amplitude and Vmax did not differ with age, the plateau was more negative and AP duration was max longer in old tissue. Aged LA cells have lower peak I<sub>Ca.L</sub> current densities than Adult LA cells (p<0.05). There were no significant differences in half-activation voltage, half-inactivation voltage and recovery time from inactivation. In addition, compared to the adult group, the Cav1.2 mRNA and protein expression of LA decreased in the aged group. <h3>Conclusions</h3> The lower plateau potential of AP and the decreased ICaL of LA in aged canines may contribute to the slow conduction and discontinuous conduction of LA. These changes increased susceptibility of aged atria to atrial fibrillation. At the same time, the decreased expression of Cav1.2 with age may be the basis of the decrease of ICaL with age." @default.
- W2335586463 created "2016-06-24" @default.
- W2335586463 creator A5019206804 @default.
- W2335586463 creator A5022827883 @default.
- W2335586463 creator A5023757533 @default.
- W2335586463 creator A5035084694 @default.
- W2335586463 creator A5081783377 @default.
- W2335586463 creator A5083089425 @default.
- W2335586463 date "2011-10-01" @default.
- W2335586463 modified "2023-10-16" @default.
- W2335586463 title "Changes in the ageing-associated of L-type calcium channel of the left Atria of the canines" @default.
- W2335586463 doi "https://doi.org/10.1136/heartjnl-2011-300867.197" @default.
- W2335586463 hasPublicationYear "2011" @default.
- W2335586463 type Work @default.
- W2335586463 sameAs 2335586463 @default.
- W2335586463 citedByCount "0" @default.
- W2335586463 crossrefType "journal-article" @default.
- W2335586463 hasAuthorship W2335586463A5019206804 @default.
- W2335586463 hasAuthorship W2335586463A5022827883 @default.
- W2335586463 hasAuthorship W2335586463A5023757533 @default.
- W2335586463 hasAuthorship W2335586463A5035084694 @default.
- W2335586463 hasAuthorship W2335586463A5081783377 @default.
- W2335586463 hasAuthorship W2335586463A5083089425 @default.
- W2335586463 hasBestOaLocation W23355864631 @default.
- W2335586463 hasConcept C104317684 @default.
- W2335586463 hasConcept C117499352 @default.
- W2335586463 hasConcept C126322002 @default.
- W2335586463 hasConcept C134018914 @default.
- W2335586463 hasConcept C134306372 @default.
- W2335586463 hasConcept C147944092 @default.
- W2335586463 hasConcept C185263204 @default.
- W2335586463 hasConcept C18699975 @default.
- W2335586463 hasConcept C2779161974 @default.
- W2335586463 hasConcept C2780030769 @default.
- W2335586463 hasConcept C33923547 @default.
- W2335586463 hasConcept C500499127 @default.
- W2335586463 hasConcept C519063684 @default.
- W2335586463 hasConcept C55493867 @default.
- W2335586463 hasConcept C71924100 @default.
- W2335586463 hasConcept C85265743 @default.
- W2335586463 hasConcept C85520022 @default.
- W2335586463 hasConcept C86803240 @default.
- W2335586463 hasConceptScore W2335586463C104317684 @default.
- W2335586463 hasConceptScore W2335586463C117499352 @default.
- W2335586463 hasConceptScore W2335586463C126322002 @default.
- W2335586463 hasConceptScore W2335586463C134018914 @default.
- W2335586463 hasConceptScore W2335586463C134306372 @default.
- W2335586463 hasConceptScore W2335586463C147944092 @default.
- W2335586463 hasConceptScore W2335586463C185263204 @default.
- W2335586463 hasConceptScore W2335586463C18699975 @default.
- W2335586463 hasConceptScore W2335586463C2779161974 @default.
- W2335586463 hasConceptScore W2335586463C2780030769 @default.
- W2335586463 hasConceptScore W2335586463C33923547 @default.
- W2335586463 hasConceptScore W2335586463C500499127 @default.
- W2335586463 hasConceptScore W2335586463C519063684 @default.
- W2335586463 hasConceptScore W2335586463C55493867 @default.
- W2335586463 hasConceptScore W2335586463C71924100 @default.
- W2335586463 hasConceptScore W2335586463C85265743 @default.
- W2335586463 hasConceptScore W2335586463C85520022 @default.
- W2335586463 hasConceptScore W2335586463C86803240 @default.
- W2335586463 hasIssue "Suppl 3" @default.
- W2335586463 hasLocation W23355864631 @default.
- W2335586463 hasOpenAccess W2335586463 @default.
- W2335586463 hasPrimaryLocation W23355864631 @default.
- W2335586463 hasRelatedWork W2003842308 @default.
- W2335586463 hasRelatedWork W2040648666 @default.
- W2335586463 hasRelatedWork W2060185396 @default.
- W2335586463 hasRelatedWork W2064236298 @default.
- W2335586463 hasRelatedWork W2095093072 @default.
- W2335586463 hasRelatedWork W2113656965 @default.
- W2335586463 hasRelatedWork W2368931477 @default.
- W2335586463 hasRelatedWork W2383647807 @default.
- W2335586463 hasRelatedWork W2385147139 @default.
- W2335586463 hasRelatedWork W2416220081 @default.
- W2335586463 hasVolume "97" @default.
- W2335586463 isParatext "false" @default.
- W2335586463 isRetracted "false" @default.
- W2335586463 magId "2335586463" @default.
- W2335586463 workType "article" @default.