Matches in SemOpenAlex for { <https://semopenalex.org/work/W2335618037> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2335618037 abstract "Objectives To trace and evaluate intracoronary transplanted mesenchymal stem cells (MSCs) labelled with superparamagnetic iron oxide (SPIO) by using magnetic resonance imaging (MRI) in a swine model of myocardial infarction (MI). Methods After isolated by density gradient centrifugation, autologous MSCs were transfected with green fluorescent protein (GFP) by lentiviral vector and labelled by superparamagnetic iron oxide (SPIO). Two weeks after MI, swine were randomised to intracoronary transplantation of dual-labelled MSCs (n=10), MSCs-GFP (n=10) and saline (n=5). MRI examination was performed with a 1.5T clinical scanner at 24 h, three weeks and eight weeks after cells transplantation. Signal intensity (SI) changes, cardiac function and MI size were measured using MRI. Correlation between MR findings and histomorphologic findings was also investigated. Results It was demonstrated that when MSCs were labelled with SPIO (25 µg Fe/ml plus 0.8 µl/ml lipofectamine) the labeling efficiency reached 95%∼l00%, with no effects on GFP expression. Multipotentiality was not affected especially for cardiomyocyte-like cells differentiation. SI on T2*WI decreased substantially in the interventricular septum 24 h after injection of MSCs. Changes in SI at 24 h, three weeks and eight weeks were (52.98±10.74)%, (21.53±5.40)% and (6.23±2.01)%, respectively (p Conclusions In vivo long-term tracing of dual-labelled MSCs can be achieved by MRI. Intracoronary transplantation of dual-labelled MSCs can increase cardiac function and reduce the size of MI." @default.
- W2335618037 created "2016-06-24" @default.
- W2335618037 creator A5002568038 @default.
- W2335618037 creator A5005522695 @default.
- W2335618037 creator A5019148423 @default.
- W2335618037 creator A5042973871 @default.
- W2335618037 creator A5058620963 @default.
- W2335618037 creator A5065734386 @default.
- W2335618037 creator A5066266117 @default.
- W2335618037 creator A5073158271 @default.
- W2335618037 creator A5078009705 @default.
- W2335618037 date "2011-10-01" @default.
- W2335618037 modified "2023-09-29" @default.
- W2335618037 title "Outcome of transplanted mesenchymal stem cells labelled with superparamagnetic iron oxide after myocardial infarction in swine" @default.
- W2335618037 doi "https://doi.org/10.1136/heartjnl-2011-300867.207" @default.
- W2335618037 hasPublicationYear "2011" @default.
- W2335618037 type Work @default.
- W2335618037 sameAs 2335618037 @default.
- W2335618037 citedByCount "0" @default.
- W2335618037 crossrefType "journal-article" @default.
- W2335618037 hasAuthorship W2335618037A5002568038 @default.
- W2335618037 hasAuthorship W2335618037A5005522695 @default.
- W2335618037 hasAuthorship W2335618037A5019148423 @default.
- W2335618037 hasAuthorship W2335618037A5042973871 @default.
- W2335618037 hasAuthorship W2335618037A5058620963 @default.
- W2335618037 hasAuthorship W2335618037A5065734386 @default.
- W2335618037 hasAuthorship W2335618037A5066266117 @default.
- W2335618037 hasAuthorship W2335618037A5073158271 @default.
- W2335618037 hasAuthorship W2335618037A5078009705 @default.
- W2335618037 hasBestOaLocation W23356180371 @default.
- W2335618037 hasConcept C126322002 @default.
- W2335618037 hasConcept C126838900 @default.
- W2335618037 hasConcept C142724271 @default.
- W2335618037 hasConcept C143409427 @default.
- W2335618037 hasConcept C198826908 @default.
- W2335618037 hasConcept C2911091166 @default.
- W2335618037 hasConcept C2989005 @default.
- W2335618037 hasConcept C500558357 @default.
- W2335618037 hasConcept C71924100 @default.
- W2335618037 hasConceptScore W2335618037C126322002 @default.
- W2335618037 hasConceptScore W2335618037C126838900 @default.
- W2335618037 hasConceptScore W2335618037C142724271 @default.
- W2335618037 hasConceptScore W2335618037C143409427 @default.
- W2335618037 hasConceptScore W2335618037C198826908 @default.
- W2335618037 hasConceptScore W2335618037C2911091166 @default.
- W2335618037 hasConceptScore W2335618037C2989005 @default.
- W2335618037 hasConceptScore W2335618037C500558357 @default.
- W2335618037 hasConceptScore W2335618037C71924100 @default.
- W2335618037 hasLocation W23356180371 @default.
- W2335618037 hasOpenAccess W2335618037 @default.
- W2335618037 hasPrimaryLocation W23356180371 @default.
- W2335618037 hasRelatedWork W1911619606 @default.
- W2335618037 hasRelatedWork W1992035908 @default.
- W2335618037 hasRelatedWork W2052792078 @default.
- W2335618037 hasRelatedWork W2064641790 @default.
- W2335618037 hasRelatedWork W2084721303 @default.
- W2335618037 hasRelatedWork W2094874400 @default.
- W2335618037 hasRelatedWork W2136880696 @default.
- W2335618037 hasRelatedWork W2280997944 @default.
- W2335618037 hasRelatedWork W2325881008 @default.
- W2335618037 hasRelatedWork W2356172798 @default.
- W2335618037 hasRelatedWork W2363000680 @default.
- W2335618037 hasRelatedWork W2367067377 @default.
- W2335618037 hasRelatedWork W2367791274 @default.
- W2335618037 hasRelatedWork W2374123909 @default.
- W2335618037 hasRelatedWork W2509681481 @default.
- W2335618037 hasRelatedWork W2591308561 @default.
- W2335618037 hasRelatedWork W2955204761 @default.
- W2335618037 hasRelatedWork W3031320511 @default.
- W2335618037 hasRelatedWork W2784887485 @default.
- W2335618037 hasRelatedWork W3145642933 @default.
- W2335618037 isParatext "false" @default.
- W2335618037 isRetracted "false" @default.
- W2335618037 magId "2335618037" @default.
- W2335618037 workType "article" @default.