Matches in SemOpenAlex for { <https://semopenalex.org/work/W2335639472> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2335639472 abstract "Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DCγ-TmT, a tocopherol mixture that is rich in γ-tocopherol (γ-T), containing 56.8% γ-T, 24.3% δ-T, 13.0% α-T and 1.5% β-T, has been shown to inhibit colon, lung, mammary and prostate tumorigenesis in our previous studies, whereas α-T was ineffective. The present work investigated the inhibition of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced prostate carcinogenesis in CYP1A-humanized (hCYP1A) mice by γ-TmT. Male hCYP1A mice, maintained on the AIN93M diet or the same diet supplemented with 0.3% γ-TmT, were treated with a dose of PhIP (200 mg/kg, i.g.). At week 40 after PhIP treatment, all mice developed high-grade prostate intraepithelial neoplasia (hgPIN) in the dorso-lateral glands. The hgPIN was associated with elevated levels of 8-oxo-deoxyguanosine (8-oxo-dG), DNMT1, COX-2 and p-AKT, as well as with loss of expression of the tumor suppressor PTEN, E-cadherin, GSTP1 and Nrf2 in the dorso-lateral glands. In the γ-TmT group, the number of glands with hgPIN (per 100 glands) was significantly lower than the control group (14.6 ± 4.87 vs. 34.81 ± 3.87, p < 0.01). The γ-TmT treatment also prevented the elevation of 8-oxo-dG, COX-2 and p-AKT and the loss of PTEN and Nrf2. The γ-TmT treatment significantly increased the plasma levels of γ-T and δ-T (to 1.7 and 0.8 μM, respectively) as well as their side-chain degradation metabolites, carboxyethyl hydroxychromans and carboxymethylbutyl hydroxychromans (to 2.6-4.0 μM, higher than their parent tocopherols). In a short-term experiment, PhIP-treatment elevated levels of 8-oxo-dG, γH2AX and DNMT1, and caused gene expression changes in several p53-associated genes, including p53bp1, p21WAF1/CIP1, cyclin D1, Bax, Igf1 and cyclinG1 at 1 and/or 3 days after PhIP treatment. Dietary γ-TmT treatment partially prevented the elevation of 8-oxo-dG, γH2AX and DNMT1. This action may contribute to the prostate cancer preventive effect of tocopherols. The presently observed inhibitory activities of γ-TmT against prostate carcinogenesis are hypothesized to be due to the decrease of oxidative stress and inhibition of AKT phosphorylation by γ- and δ-tocopherols, and this hypothesis remains to be tested further (supported by NIH grants CA159361 & CA133021).Citation Format: Guangxun Li, Hong Wang, Anna B. Liu, Jayson X. Chen, Mao-Jung Lee, Chung S. Yang. Tocopherols inhibit the dietary carcinogen PhIP-induced prostate carcinogenesis in a CYP1A-humanized mouse model. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 202. doi:10.1158/1538-7445.AM2013-202" @default.
- W2335639472 created "2016-06-24" @default.
- W2335639472 creator A5007938812 @default.
- W2335639472 creator A5012138004 @default.
- W2335639472 creator A5033020983 @default.
- W2335639472 creator A5076155909 @default.
- W2335639472 creator A5082769654 @default.
- W2335639472 creator A5086188593 @default.
- W2335639472 date "2013-04-15" @default.
- W2335639472 modified "2023-09-27" @default.
- W2335639472 title "Abstract 202: Tocopherols inhibit the dietary carcinogen PhIP-induced prostate carcinogenesis in a CYP1A-humanized mouse model." @default.
- W2335639472 doi "https://doi.org/10.1158/1538-7445.am2013-202" @default.
- W2335639472 hasPublicationYear "2013" @default.
- W2335639472 type Work @default.
- W2335639472 sameAs 2335639472 @default.
- W2335639472 citedByCount "0" @default.
- W2335639472 crossrefType "proceedings-article" @default.
- W2335639472 hasAuthorship W2335639472A5007938812 @default.
- W2335639472 hasAuthorship W2335639472A5012138004 @default.
- W2335639472 hasAuthorship W2335639472A5033020983 @default.
- W2335639472 hasAuthorship W2335639472A5076155909 @default.
- W2335639472 hasAuthorship W2335639472A5082769654 @default.
- W2335639472 hasAuthorship W2335639472A5086188593 @default.
- W2335639472 hasConcept C114246631 @default.
- W2335639472 hasConcept C121608353 @default.
- W2335639472 hasConcept C126322002 @default.
- W2335639472 hasConcept C134018914 @default.
- W2335639472 hasConcept C178790620 @default.
- W2335639472 hasConcept C185592680 @default.
- W2335639472 hasConcept C190283241 @default.
- W2335639472 hasConcept C2776235491 @default.
- W2335639472 hasConcept C2777609662 @default.
- W2335639472 hasConcept C2779534503 @default.
- W2335639472 hasConcept C2780192828 @default.
- W2335639472 hasConcept C502942594 @default.
- W2335639472 hasConcept C55493867 @default.
- W2335639472 hasConcept C555283112 @default.
- W2335639472 hasConcept C71924100 @default.
- W2335639472 hasConcept C75217442 @default.
- W2335639472 hasConcept C86554907 @default.
- W2335639472 hasConceptScore W2335639472C114246631 @default.
- W2335639472 hasConceptScore W2335639472C121608353 @default.
- W2335639472 hasConceptScore W2335639472C126322002 @default.
- W2335639472 hasConceptScore W2335639472C134018914 @default.
- W2335639472 hasConceptScore W2335639472C178790620 @default.
- W2335639472 hasConceptScore W2335639472C185592680 @default.
- W2335639472 hasConceptScore W2335639472C190283241 @default.
- W2335639472 hasConceptScore W2335639472C2776235491 @default.
- W2335639472 hasConceptScore W2335639472C2777609662 @default.
- W2335639472 hasConceptScore W2335639472C2779534503 @default.
- W2335639472 hasConceptScore W2335639472C2780192828 @default.
- W2335639472 hasConceptScore W2335639472C502942594 @default.
- W2335639472 hasConceptScore W2335639472C55493867 @default.
- W2335639472 hasConceptScore W2335639472C555283112 @default.
- W2335639472 hasConceptScore W2335639472C71924100 @default.
- W2335639472 hasConceptScore W2335639472C75217442 @default.
- W2335639472 hasConceptScore W2335639472C86554907 @default.
- W2335639472 hasLocation W23356394721 @default.
- W2335639472 hasOpenAccess W2335639472 @default.
- W2335639472 hasPrimaryLocation W23356394721 @default.
- W2335639472 hasRelatedWork W1825684926 @default.
- W2335639472 hasRelatedWork W1963499926 @default.
- W2335639472 hasRelatedWork W2015346934 @default.
- W2335639472 hasRelatedWork W2032397221 @default.
- W2335639472 hasRelatedWork W2057986789 @default.
- W2335639472 hasRelatedWork W2074771706 @default.
- W2335639472 hasRelatedWork W2076683184 @default.
- W2335639472 hasRelatedWork W2091876554 @default.
- W2335639472 hasRelatedWork W2102805738 @default.
- W2335639472 hasRelatedWork W2116891307 @default.
- W2335639472 hasRelatedWork W2119387349 @default.
- W2335639472 hasRelatedWork W2139862399 @default.
- W2335639472 hasRelatedWork W2177294379 @default.
- W2335639472 hasRelatedWork W2315550008 @default.
- W2335639472 hasRelatedWork W2318360263 @default.
- W2335639472 hasRelatedWork W2332203406 @default.
- W2335639472 hasRelatedWork W2482766045 @default.
- W2335639472 hasRelatedWork W2563422249 @default.
- W2335639472 hasRelatedWork W2762007252 @default.
- W2335639472 hasRelatedWork W3085229194 @default.
- W2335639472 isParatext "false" @default.
- W2335639472 isRetracted "false" @default.
- W2335639472 magId "2335639472" @default.
- W2335639472 workType "article" @default.