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- W2335661946 abstract "Introduction: In patients responding successfully to ART, the next therapeutic step is viral cure. An interesting strategy is antiviral vaccination, particularly involving CD8 T cell epitopes. Assuming that the resuming viral replication originates from proviral DNA, the Provir/Latitude 45 project aims to investigate which CTL epitopes in proviral HIV-1 will be recognized by the immune system when HLA alleles are taken into consideration. Discussion: Eleven HIV-1 infected patients responding successfully to a first-line ART were enrolled in a first part of the project; the ART period ranged from 8 months to 9 years with indetectable viral load. In a second part of the study, 6 patients from the Canadian primary infection cohort were investigated at different time points after primary infection, an event that had occurred between 2.5 and 4.5 months before recruitment; 3 of them received an ART during the follow up and could be investigated at the time of ART success. After molecular characterization of HLA alleles A and B, Gag and Nef were sequenced by the Sanger method while RT was investigated by NGS. According to the HLA alleles, the CTL epitopes that could be presented were identified in RNA and /or DNA points by using the immune epitope database simulator. Variability of epitopes can be observed in circulating RNA and proviral DNA. It is not possible to predict fully which CTL epitopes have been finally archived. This finding, together with the potential affinity for the HLA groove, is to be taken into consideration in the quest for a curative vaccine. Conclusions: It may be that only a customized vaccine will prove efficient in a vaccinal strategy, given the variability of the epitopes and HLA groove affinity. Nevertheless, crucial questions are raised: Might there be variants for certain epitopes that can be observed only by NGS? Are these variants the same in the different reservoirs and particularly the circulating cells, lymph nodes and GALT? Are the detected variants associated with competent replication viruses?" @default.
- W2335661946 created "2016-06-24" @default.
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- W2335661946 date "2014-11-01" @default.
- W2335661946 modified "2023-10-06" @default.
- W2335661946 title "F-109 Why a generic vaccine may not be efficient for HIV-1 cure" @default.
- W2335661946 doi "https://doi.org/10.1097/01.qai.0000456105.42773.64" @default.
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