Matches in SemOpenAlex for { <https://semopenalex.org/work/W2335673969> ?p ?o ?g. }
- W2335673969 endingPage "8623" @default.
- W2335673969 startingPage "8613" @default.
- W2335673969 abstract "Hexabromocyclododecane (HBCD) is a globally produced brominated flame retardant (BFR) used primarily as an additive FR in polystyrene and textile products and has been the subject of intensified research, monitoring and regulatory interest over the past decade. HBCD is currently being evaluated under the Stockholm Convention on Persistent Organic Pollutants. HBCD is hydrophobic (i.e., has low water solubility) and thus partitions to organic phases in the aquatic environment (e.g., lipids, suspended solids). It is ubiquitous in the global environment with monitoring data generally exhibiting the expected relationship between proximity to known sources and levels; however, temporal trends are not consistent. Estimated degradation half-lives, together with data in abiotic compartments and long-range transport potential indicate HBCD may be sufficiently persistent and distributed to be of global concern. The detection of HBCD in biota in the Arctic and in source regions and available bioaccumulation data also support the case for regulatory scrutiny. Toxicity testing has detected reproductive, developmental and behavioral effects in animals where exposures are sufficient. Recent toxicological advances include a better mechanistic understanding of how HBCD can interfere with the hypothalamic-pituitary-thyroid axis, affect normal development, and impact the central nervous system; however, levels in biota in remote locations are below known effects thresholds. For many regulatory criteria, there are substantial uncertainties that reduce confidence in evaluations and thereby confound management decision-making based on currently available information." @default.
- W2335673969 created "2016-06-24" @default.
- W2335673969 creator A5004323872 @default.
- W2335673969 creator A5032022286 @default.
- W2335673969 creator A5042123511 @default.
- W2335673969 creator A5046956525 @default.
- W2335673969 creator A5080464747 @default.
- W2335673969 creator A5081313381 @default.
- W2335673969 creator A5082673258 @default.
- W2335673969 date "2011-09-23" @default.
- W2335673969 modified "2023-10-16" @default.
- W2335673969 title "Hexabromocyclododecane: Current Understanding of Chemistry, Environmental Fate and Toxicology and Implications for Global Management" @default.
- W2335673969 cites W145630242 @default.
- W2335673969 cites W1523791335 @default.
- W2335673969 cites W1963492292 @default.
- W2335673969 cites W1964883829 @default.
- W2335673969 cites W1966283710 @default.
- W2335673969 cites W1967617048 @default.
- W2335673969 cites W1968358972 @default.
- W2335673969 cites W1973793870 @default.
- W2335673969 cites W1977083155 @default.
- W2335673969 cites W1977369538 @default.
- W2335673969 cites W1982783934 @default.
- W2335673969 cites W1982849616 @default.
- W2335673969 cites W1983245300 @default.
- W2335673969 cites W1983435499 @default.
- W2335673969 cites W1985361712 @default.
- W2335673969 cites W1985644728 @default.
- W2335673969 cites W1990400942 @default.
- W2335673969 cites W1991667072 @default.
- W2335673969 cites W2001315330 @default.
- W2335673969 cites W2001634827 @default.
- W2335673969 cites W2001772808 @default.
- W2335673969 cites W2003208114 @default.
- W2335673969 cites W2003663181 @default.
- W2335673969 cites W2005101127 @default.
- W2335673969 cites W2009129666 @default.
- W2335673969 cites W2009476218 @default.
- W2335673969 cites W2011670059 @default.
- W2335673969 cites W2011802749 @default.
- W2335673969 cites W2012741802 @default.
- W2335673969 cites W2013024553 @default.
- W2335673969 cites W2014852438 @default.
- W2335673969 cites W2015629947 @default.
- W2335673969 cites W2019561776 @default.
- W2335673969 cites W2020515863 @default.
- W2335673969 cites W2020528796 @default.
- W2335673969 cites W2021118503 @default.
- W2335673969 cites W2022772992 @default.
- W2335673969 cites W2023947582 @default.
- W2335673969 cites W2025626506 @default.
- W2335673969 cites W2028338197 @default.
- W2335673969 cites W2030612692 @default.
- W2335673969 cites W2032206642 @default.
- W2335673969 cites W2032663824 @default.
- W2335673969 cites W2036274594 @default.
- W2335673969 cites W2039671512 @default.
- W2335673969 cites W2040327624 @default.
- W2335673969 cites W2041637384 @default.
- W2335673969 cites W2042036197 @default.
- W2335673969 cites W2045627369 @default.
- W2335673969 cites W2048821479 @default.
- W2335673969 cites W2049081192 @default.
- W2335673969 cites W2050374723 @default.
- W2335673969 cites W2051612311 @default.
- W2335673969 cites W2052154025 @default.
- W2335673969 cites W2052316085 @default.
- W2335673969 cites W2052671208 @default.
- W2335673969 cites W2054745690 @default.
- W2335673969 cites W2056539801 @default.
- W2335673969 cites W2058971325 @default.
- W2335673969 cites W2059616974 @default.
- W2335673969 cites W2061127986 @default.
- W2335673969 cites W2061245238 @default.
- W2335673969 cites W2063555463 @default.
- W2335673969 cites W2068851177 @default.
- W2335673969 cites W2068939542 @default.
- W2335673969 cites W2070898361 @default.
- W2335673969 cites W2070968636 @default.
- W2335673969 cites W2071136533 @default.
- W2335673969 cites W2073404756 @default.
- W2335673969 cites W2073697610 @default.
- W2335673969 cites W2080824610 @default.
- W2335673969 cites W2082802165 @default.
- W2335673969 cites W2082866970 @default.
- W2335673969 cites W2084947241 @default.
- W2335673969 cites W2085236959 @default.
- W2335673969 cites W2086966017 @default.
- W2335673969 cites W2090594391 @default.
- W2335673969 cites W2094452874 @default.
- W2335673969 cites W2097283165 @default.
- W2335673969 cites W2099307412 @default.
- W2335673969 cites W2103275378 @default.
- W2335673969 cites W2110646025 @default.
- W2335673969 cites W2111422484 @default.
- W2335673969 cites W2119446591 @default.
- W2335673969 cites W2121516119 @default.
- W2335673969 cites W2121888297 @default.