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• W2335675800 endingPage "783" @default.
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• W2335675800 abstract "症例は72歳，男性．2003年肝細胞癌初発し，RFAを施行．以後，再発癌に対し，TACEやRFAを行ってきたが，2009年1月肺転移，胸壁転移が出現した．全身化学療法を含む集学的治療を行うも奏功せず，2010年4月3日よりsorafenib 800 mg/dayを導入した．副作用として，手足皮膚反応や下痢，倦怠感が出現したため，適宜，減量，休薬にて投与量の調節を行い，11月30日よりsorafenib 400 mg/dayを投与継続中で，副作用も自制内であった．2011年1月4日，急性腹症にて救急外来受診，CTにて骨盤内にfree airを認め，腸管穿孔と診断，S状結腸切除および人工肛門造設術を施行した．術後，合併症無く経過している．肝細胞癌に対するsorafenib内服中に消化管穿孔を合併した症例を経験したので報告する．" @default.
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• W2335675800 date "2011-01-01" @default.
• W2335675800 modified "2023-10-14" @default.
• W2335675800 title "A case report of perforation of the colon during the sorafenib therapy for hepatocellular carcinoma" @default.
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• W2335675800 doi "https://doi.org/10.2957/kanzo.52.777" @default.
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