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• W2335737128 abstract "Event Abstract Back to Event Aging and cognitive control over action: diffusion measures of white matter integrity and connection strength predict stopping performance James P. Coxon1*, Annouchka Van Impe1, Nicole Wenderoth1 and Stephan P. Swinnen1 1 K.U. Leuven, Belgium Structural integrity of brain white matter declines in old age, with the most pronounced changes occurring in tracts connecting anterior brain regions. Despite observations that inhibitory control is diminished in the elderly, it is not known whether this is related to the deterioration of frontal white matter, and whether this is specific to task relevant pathways. Right-handed participants (20 old and 20 young, mean age 69 and 25 years) performed a stop-signal task probing both non-selective and more selective aspects of behavioural inhibition. Go trials (70%) required a simultaneous response by both hands. Stop trials required the rapid inhibition of both (Stop All, 10%), or just one (Stop Left, 10%, Stop Right, 10%) hand. As expected stop-signal reaction time (SSRT) was worse in the older group and interference effects were greater during selective stopping. When young adults perform stop-signal tasks, activation of right inferior frontal cortex (IFC), pre-supplementary motor area (preSMA) and subthalamic nucleus (STN) is observed. We therefore outlined STN manually on enhanced contrast anatomical scans, performed probabilistic diffusion tractography, and extracted measures of tract strength and integrity to investigate brain-behaviour relationships. Structural integrity (fractional anisotropy, FA) of white matter associated with right (but not left) IFC, preSMA and bilateral STN regions of interest was related to individual differences in SSRT and interference effects. Bilateral preSMA-STN tract connection strength predicted SSRT and this relationship was strongest in the elderly. This result highlights the importance of bilateral preSMA-STN projections in reactive stopping and links age-related decline in inhibitory control with structural decline of this pathway. Funding: Supported by Flanders Fund for Scientific Research - FWO (G.0593.08, G.0483.10); J.P.C is supported by a FWO Postdoctoral fellowship. Keywords: Aging, white matter Conference: XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011. Presentation Type: Poster Presentation Topic: Poster Sessions: Cognitive Aging Citation: Coxon JP, Van Impe A, Wenderoth N and Swinnen SP (2011). Aging and cognitive control over action: diffusion measures of white matter integrity and connection strength predict stopping performance. Conference Abstract: XI International Conference on Cognitive Neuroscience (ICON XI). doi: 10.3389/conf.fnhum.2011.207.00610 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 15 Nov 2011; Published Online: 28 Nov 2011. * Correspondence: Dr. James P Coxon, K.U. Leuven, Leuven, Belgium, james.coxon@faber.kuleuven.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers James P Coxon Annouchka Van Impe Nicole Wenderoth Stephan P Swinnen Google James P Coxon Annouchka Van Impe Nicole Wenderoth Stephan P Swinnen Google Scholar James P Coxon Annouchka Van Impe Nicole Wenderoth Stephan P Swinnen PubMed James P Coxon Annouchka Van Impe Nicole Wenderoth Stephan P Swinnen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2335737128 title "Aging and cognitive control over action: diffusion measures of white matter integrity and connection strength predict stopping performance" @default.
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