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- W2335757946 abstract "Background: IL-2 represents yet an alternative to targeted therapy for metastatic renal cancer (mRCC) treatment. Prior studies have suggested high dose bolus as the preferred administration modality. However, its use is limited by toxicity and the search for an alternative modality is justified. In order to reduce toxicity we evaluated feasibility, dose limiting toxicity (DLT) and activity of IL-2 chrono-infusion in mRCC. Methods: Patients (pts) with mRCC were treated with IL-2 which was administered with an escalated dose in 8 hour chrono-infusion (peak 1am, 9am, and 5pm) from 2 MUI/m 2 according to Fibonacci scale. Results: 22 pts were enrolled. 3 pts entered each Level I to V and 7 entered VI. Grade 3-4 toxicities were reported only in 4 cases (2 hypotension and renal, 1 diarrhoea) on the VI Level. DLT was 18.6 MUI/m2. Overall response rate was 14% (23% in a good-intermediate risk group). Median PFS and OS were 4.5 and 14.5 months respectively. In an univariate analysis dose level, PS, gender, cD3, cD4, cD8 counts were statistically significant for OS. Conclusion: IL-2 chrono-infusion appears safe in a standard care unit, moderately" @default.
- W2335757946 created "2016-06-24" @default.
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- W2335757946 date "2014-01-01" @default.
- W2335757946 modified "2023-09-25" @default.
- W2335757946 title "Chrono-Immunotherapy with Interleukin-2 for Treatment of Metastatic Renal Cell Carcinoma: A Phase I-II Study" @default.
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