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• W2335773034 startingPage "1681" @default.
• W2335773034 abstract "The transmembrane subunit (gp41) of the HIV envelope protein complex (Env) mediates the viral fusion step of HIV entry. The membrane proximal external region (MPER), one of the functional domains of gp41, has been the focus of a great deal of research because it is a target for neutralizing antibodies. In this study, we examined 23 amino acid residues in the MPER (660–683) in both a CXCR4 coreceptor-utilizing strain (HXB2) and a CCR5-utilizing strain (JRFL) by alanine scanning mutagenesis. Despite the high degree of gp41 sequence conservation, the effects of alanine mutation in the MPER were different between the two strains. Most mutations in HXB2 had fusogenicity and protein expression levels not less than 50% of that of the wild type in the case of cell–cell fusion. However, ∼30% of the mutants in HXB2 showed a severe defect in fusogenicity in viral entry. Mutations in the MPER of strain JRFL had more dramatic effects than that in HXB2 in cell–cell fusion and viral entry. The fact that there are large differences in the effects of mutation between two strains suggests the potential for the interaction of the MPER with nonconserved sequences such as the fusion peptide and/or other NHR domains as well as potential long-range structural effects on the conformational changes that occur with the Env complex during membrane fusion." @default.
• W2335773034 created "2016-06-24" @default.
• W2335773034 creator A5036110838 @default.
• W2335773034 creator A5049763724 @default.
• W2335773034 creator A5058029445 @default.
• W2335773034 creator A5087297216 @default.
• W2335773034 date "2015-02-19" @default.
• W2335773034 modified "2023-10-14" @default.
• W2335773034 title "The Membrane Proximal External Regions of gp41 from HIV-1 Strains HXB2 and JRFL Have Different Sensitivities to Alanine Mutation" @default.
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• W2335773034 doi "https://doi.org/10.1021/bi501171r" @default.
• W2335773034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4684184" @default.
• W2335773034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25649507" @default.
• W2335773034 hasPublicationYear "2015" @default.
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