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• W2335844061 abstract "ABSTRACT Aim: This survey verified reproducibility in the real world of the survival data reported in the literature. Methods: This study reviewed individual data of 1238 pts treated with TT from mid 2007 to December 2012 in 35 Italian Institutions. Results: Median age was 66 yrs (range 24-91). Histology was clear cell (CC) (84%), with sarcomatoid component (7%), others (9%); nephrectomy was performed in 88% of the pts and 36.5% of the pts presented with ≥3 metastatic sites. PS (ECOG) was 0 in 53%, 1 in 34%, ≥2 in 9%, ne in 4% of the pts. Median OS (mOS) was 24 mo. Sunitinib (su) was the 1stline (ln) therapy (tx) in 964 pts (78%), sorafenib (so) in 152 (12%), temsirolimus (tem) in 51 (4%), others in 71 (5%). Response rate to 1st ln tx was: CR 4%, PR 31%, SD 30%, PD 28%, ne 7%. In 918 evaluable pts, MSKCC risk score was poor (10%), intermediate (46%) and good (18%). Dose reduction was required in 46%; 39% of the pts had a duration of 1st ln tx 6 mo, no tx interruption, no dose reduction were statistically related to execution of 2nd line tx. Cox multivariate analysis showed that execution of 2nd line tx, no dose reduction, type of drug, 1st ln duration >6 mo, CC histology, no tx interruption, MSKCC risk score, PS, type of response were statistically related to OS. mOS (all p Nephrectomy vs not 28 / 6.5 Metastatic sites ≤2 vs ≥3 31 / 18 PS 0 vs 1 vs ≥2 38.5 /18.6 / 6 CR vs PR vs SD vs PD 62.5 /39 / 29 / 7.8 Poor vs intermediate vs good MSKCC risk score 6.4 / 26 /46 Dose reduction: yes vs not 19.8 / 33.6 1st ln duration 6 mo 9.1 / 36.5 Conclusions: This large survey: i) confirmed survival data for the individual drugs ii) identified predictive and prognostic factors iii) showed similar OS between the principal sequences of tx. Disclosure: All authors have declared no conflicts of interest." @default.
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• W2335844061 date "2014-09-01" @default.
• W2335844061 modified "2023-10-14" @default.
• W2335844061 title "Metastatic Renal Cell Carcinoma (Mrcc) Treated with Targeted Therapies (Tt) in the Community Setting: an Italian Survey on 1238 Pts" @default.
• W2335844061 doi "https://doi.org/10.1093/annonc/mdu337.34" @default.
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